Fasting mimetic may improve cardiometabolic health markers: RCT

A randomized, double-blind, placebo-controlled trial found that an eight-week supplementation with a fasting mimetic containing spermidine, nicotinamide, PEA, and OEA led to significant improvements in cholesterol, fasting glucose, and hunger regulation in older adults with elevated cardiometabolic risk. The study, conducted remotely using People Science’s digital platform, demonstrated that the supplement mimicked some metabolic benefits of fasting, including improved appetite control and reduced abdominal discomfort, without requiring participants to skip meals.