GLP-1s: Could ketone esters prevent muscle loss for semaglutide users?

A recent study in lab mice suggests that ketone ester supplementation may help preserve muscle mass and strength in semaglutide users without diminishing fat loss. Researchers found that co-administering ketone esters with semaglutide prevented muscle atrophy and maintained mitochondrial function, counteracting negative changes typically induced by the drug. While these preclinical results are promising and indicate potential for ketone therapy to protect muscle during GLP-1RA treatment, experts emphasize that further clinical studies in humans are necessary to confirm these effects.