Insilico agreed to apply its Pharma.AI platform, which addresses target validation, generative chemistry, and molecule optimization, along with its preclinical drug discovery expertise to discover, design, and optimize candidates for neuroimmune indications against targets that will originate with SK. SK will contribute its development and clinical capabilities in neuroimmune disorders, steering the late-stage development and commercialization of all resulting programs.
The post Insilico, SK Launch Up-to-$2.5B Neuroimmune AI Drug Collaboration appeared first on GEN - Genetic Engineering and Biotechnology News.
The company, which emerged from stealth this week, is using the funds to develop and test three therapeutic assets that it licensed from external partners as well as to progress some additional preclinical assets.
The post Backed by $165M, Bionyra Pharma Launches to Advance Inflammatory Disease Biologics appeared first on GEN - Genetic Engineering and Biotechnology News.
This GEN Live show will bring together a panel of leading experts to break down the latest advances, innovations, and challenges shaping genome editing.
The post Genome Editing at the Turning Point—Bringing CRISPR to Clinical Reality appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers identified the protein MUC16 as a clinically relevant target for bladder cancer, and engineered MUC16-targeting CAR T cells that, when delivered into the bladder via a catheter, controlled bladder tumors in mice.
The post Intravesical CAR T-Cell Therapy Reduces Bladder Cancer Growth in Preclinical Model appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers developed the first human antibody cocktail to completely protect against the lethal Nipah and Hendra virus infection in preclinical models, advancing a promising dual-target strategy for future outbreaks.
The post Nipah and Hendra Viruses: Antibody Cocktail Provides Complete Protection in Hamster Model appeared first on GEN - Genetic Engineering and Biotechnology News.
Circio and Tcelltech will combine Circio's circVec circular RNA expression technology with Tcelltech's non-viral, high-cargo capacity nanoSMAR vector platform and evaluate the combination in engineered T cells through staged research.
The post Circio’s circVec and Tcelltech’s nanoSMAR Technologies Combined to Generate Nextgen <i>In vivo</i> CAR-T and TCR-T Cells appeared first on GEN - Genetic Engineering and Biotechnology News.
A human‑in‑the‑loop AI framework rapidly nominates CAR T targets, leading to a GPNMB‑directed CAR T cell with activity across melanoma, leukemia, and colorectal cancer in preclinical studies.
The post AI Framework Surfaces New CAR T Target with Multi‑Cancer Potential appeared first on GEN - Genetic Engineering and Biotechnology News.
Using a genetic system in E. coli, researchers discovered how bacteria work as a team to survive antibiotics, with donor cells exporting and sharing vesicle-bound proteins with populations of less active persister cells.
The post Antibiotics Trigger Protein Sharing Among Bacteria, Aiding Persister Cells appeared first on GEN - Genetic Engineering and Biotechnology News.
The deal would add Bio-Techne’s multiomics offerings, analytical technologies, and integrated workflow solutions to German Merck’s platforms and services in research, bioprocessing and advanced therapeutics, with the aim of creating a combined company capable of helping customers from discovery and translational research through development, testing and commercial manufacturing.
The post Merck KGaA to Acquire Bio-Techne for $11.3B, Expanding Life Science Tools Presence appeared first on GEN - Genetic Engineering and Biotechnology News.
The panel, which featured the acting directors of Center for Drug Evaluation and Research and the Center for Biologics Evaluation and Research, and the acting chief of staff, focused on the FDA’s current priorities and initiatives.
The post BIO 2026: FDA Leadership Confront Workforce Losses, China Competition in Drug Development appeared first on GEN - Genetic Engineering and Biotechnology News.
Lonza and InduPro signed the licensing agreement to develop differentiated therapeutic approaches designed to address complex diseases such as cancer, where precision targeting and efficacy remain critically important.
The post InduPro Licenses Lonza’s Linker Payload Technologies and Bioconjugation Platforms appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers uncovered a biological pathway that explains why high-cholesterol diets reduce the body's ability to clear harmful LDL cholesterol from the blood and identified a clinical-stage drug candidate that could potentially target the pathway.
The post Drug Targets LDL Receptor Pathway to Control Cholesterol appeared first on GEN - Genetic Engineering and Biotechnology News.
UCI Health has launched the world’s first human clinical trial using embryonic stem cell-derived neural cells for Huntington’s disease, testing MRI-guided surgical brain delivery to evaluate safety and early therapeutic potential.
The post First-in-Human Stem Cell Therapy Trial for Huntington’s Disease Begins at UCI Health appeared first on GEN - Genetic Engineering and Biotechnology News.
John Crowley emphasized industry modernization and solving "man-made problems" to outcompete rivals like China through improved U.S. innovation ecosystems.
The post BIO 2026: CEO Calls for U.S. Biotech Urgency and International Competitiveness appeared first on GEN - Genetic Engineering and Biotechnology News.
A new feeder cell line multiplies NK cells by more than 100,000-fold in one month, making it easier to produce these therapeutic cells at commercial quantities and thus develop off-the-shelf cancer immunotherapies.
The post Novel Feeder Cell Line Dramatically Expands NK Cell Production appeared first on GEN - Genetic Engineering and Biotechnology News.
Manufacturing weight loss drugs at high volume at lower cost with less wastage could get easier thanks to a recoded E.coli strain that can produce long peptide chains containing non-natural chemistries.
The post Recoded <i>E. coli</i> Promises More Scalable Weight Loss Drug Production appeared first on GEN - Genetic Engineering and Biotechnology News.
As more than 100 clinical trials test human pluripotent stem cell-derived therapies, researchers are shifting focus from proving large-scale production is possible to building standardized, AI-enabled manufacturing systems capable of delivering consistent, clinically compliant cell products.
The post Scaling Stem-Cell Manufacturing for Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
The WHO has selected Ireland’s NIBRT as its European hub for engineering education. The aim is to give production staff skills in automation, AI, and other advanced techniques so they can build local manufacturing capacity.
The post WHO Selects NIBRT as Training Hub to Help LMICs Build Biopharma Capacity appeared first on GEN - Genetic Engineering and Biotechnology News.
The physical AI system, named AI Experimentalist, translates research goals from natural language into executable workflows that span the entire experimental cycle, from literature review, wet-lab execution, data analysis, and protocol refinement.
The post Medra Launches Reasoning Layer for Drug Discovery Robotics appeared first on GEN - Genetic Engineering and Biotechnology News.
This GEN Spotlight on RNA Therapeutics brings you three interlinked sessions that feature outstanding researchers exploring various aspects of RNA biology and therapeutics.
The post Spotlight on RNA Therapeutics appeared first on GEN - Genetic Engineering and Biotechnology News.
BIOCOM California quantified the economic impact of the Golden State’s life sciences industry as generating $394 billion in economic output in 2025—a figure that goes beyond the direct impact of the 406,505 people employed by life sciences employers across the state. However, all three of the state’s top-tier life-sci clusters—the San Francisco Bay Area, San Diego, and the Los Angeles/Orange County region—saw decreases in employment within the industry last year.
The post California Still Golden Despite Job Losses: Industry Group appeared first on GEN - Genetic Engineering and Biotechnology News.
An analysis of human lung fluid samples from hospitalized patients identified three different subtypes of severe pneumonia, a finding which the researchers say could help to explain different outcomes, and potentially inform personalized therapeutics.
The post Three Subtypes of Severe Pneumonia Might Inform Personalized Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
The toolkit turns complex scientific workflows into agent-executable tasks and has applications across protein structure prediction, molecular docking, generative chemistry, genomic analysis, protein design, and biomarker discovery.
The post Nvidia Unveils Science Reasoning AI Suite with BioNeMo Agent Toolkit appeared first on GEN - Genetic Engineering and Biotechnology News.
The aim of the partnership is to provide a platform delivering high-end performance with an optimal cost-of-goods and price-per-dose model to ease scale-up, commercial strategy, and fundraising efforts for drug developers.
The post Nextgen Platform Combines VectorBuilder and Maxcyte Technologies to Boost Clinical-Grade Cell Engineering appeared first on GEN - Genetic Engineering and Biotechnology News.
Cytomos says its benchtop cell analytics intelligence system combines the compact Celledonia analyzer with the sensors of the AuraCyt modules to transform complex cellular data into actionable insights.
The post Cytomos’ AuraCyt Digital Predictive Cell Analytics Platform Showcased at BIO Conference appeared first on GEN - Genetic Engineering and Biotechnology News.
A new gene‑network modeling framework integrating cis and trans regulatory effects identifies 766 schizophrenia‑associated genes—641 previously missed—across six brain regions.
The post Long‑Range Gene Networks Uncover 641 New Schizophrenia‑Associated Genes appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers used AI to discover antibiotic-like molecules inside prion and prion-like proteins, including candidates that reduced A. baumannii burden in mice, with efficacy comparable to polymyxin B in the model tested.
The post AI Discovers Potential Antimicrobial “Prionin” Peptides appeared first on GEN - Genetic Engineering and Biotechnology News.
Apogee’s lead candidate zumilokibart, an IL-13 inhibitor also called APG777, is a long-acting treatment that, according to the company, holds “pipeline-in-a-product potential” because of the opportunity it has for treating a variety of immunology and inflammation (I&I) diseases for which the drug is under study.
The post AbbVie to Acquire Apogee Therapeutics for $10.9B appeared first on GEN - Genetic Engineering and Biotechnology News.
Brain-infiltrating γδ T cells accumulate in a genetic autism mouse model, contributing to social deficits. Removing or blocking these immune cells improved sociability, highlighting immune dysregulation as a potential therapeutic target.
The post Brain-Infiltrating T Cells Linked to Social Deficits in Autism Mouse Model appeared first on GEN - Genetic Engineering and Biotechnology News.
TVA exposure during breastfeeding reprogrammed immune cells to improve responses to pathogens. Mice that were nursed on TVA-enriched milk responded faster to infections with viruses or common bacteria, even into adulthood.
The post Breast Milk Fatty Acid Shapes Immune Development in Mice appeared first on GEN - Genetic Engineering and Biotechnology News.
The data was strong enough for Intellia to continue the rolling Biologics License Application (BLA) submission that it began in April. The company expects to complete the BLA filing by year’s end and hopes to gain FDA approval and launch lonvo-z in the first half of 2027.
The post StockWatch: Positive Phase III Data Sells Investors on Intellia appeared first on GEN - Genetic Engineering and Biotechnology News.
Pairing the life histories of free-living macaques with genomic data from different tissues in adulthood, researchers have generated some of the clearest molecular evidence yet that early life adversity leaves a lasting, system-wide impression at the epigenome.
The post Impact of Early Life Adversity on Epigenome at Molecular Level Mapped in Macaques appeared first on GEN - Genetic Engineering and Biotechnology News.
In this episode of GEN's Touching Base, editors talk about Parabilis Medicines’ groundbreaking IPO score, a new Merck collaboration, first-in-human Lassa–Rabies vaccine data, how CRISPR is attacking cancer cells, and mRNA delivery for DMD therapy.
The post Historic Biotech IPO, Merck, Protillion’s AI Deal, Testing a Lassa–Rabies Vaccine appeared first on GEN - Genetic Engineering and Biotechnology News.
IDBS and Alchemi partnered to connect AI agents with data in the IDBS Polar platform, creating a governed data foundation that enables reliable, compliant agentic AI use throughout drug development.
The post IDBS and Alchemi Agree to Accelerate AI-Driven Biopharma Regulatory Filings appeared first on GEN - Genetic Engineering and Biotechnology News.
China’s Order 818 signals the country’s intent to accelerate local innovation and standardize the drug development environment, thereby becoming a more important player in advanced therapy development and manufacturing.
The post China Sets Framework for Advanced Therapeutic Development appeared first on GEN - Genetic Engineering and Biotechnology News.
The Ross Prize recognizes biomedical scientists whose discoveries have transformed how medicine is practiced. This year's recipients are well known in immunotherapy circles for their efforts to develop CAR T cells now used in cancer therapeutics.
The post Perseverance, Persistence Key to CAR T Success, Say Ross Prize Winners Carl June and Michel Sadelain appeared first on GEN - Genetic Engineering and Biotechnology News.
TALOS represents an advancement in protein quantitation, enabling rapid, consistent measurements with operational simplicity. These capabilities make it well-suited for modern bioprocessing workflows, from early process development through GMP manufacturing.
The post Nirrin Technologies and S.T. Japan Partner on Next-Gen Protein Quantitation Tech appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers demonstrated in a preclinical model a new method of using decellularized cartilage with patient-specific cells to create grafts for enlarging pediatric airways narrowed as a result of severe subglottic stenosis.
The post Personalized Cartilage Graft Developed for Life-Threatening Infant Airway Narrowing appeared first on GEN - Genetic Engineering and Biotechnology News.
Chromatography optimization should be considered not only in terms of quality, but also in terms of how each change affects processing time, congestion, and feasibility regarding stability-based time windows.
The post Analytics Map Purification Optimization Tradeoffs appeared first on GEN - Genetic Engineering and Biotechnology News.
An independent U.K. innovation center has developed a continuous bioprocess to improve productivity and reduce costs of advanced therapies. The new platform performs as well, or better, than batch methods.
The post Continuous Production Platform Offers New Gene Therapy Options appeared first on GEN - Genetic Engineering and Biotechnology News.
Interest in E.coli-based expression systems is growing as biopharma firms look for faster and cheaper ways of making proteins at commercial scale, prompting the new partnership between NorthX Biologics and enGenes Biotech.
The post Bacterial Expression Tech Prompts NorthX and enGenes Collaboration appeared first on GEN - Genetic Engineering and Biotechnology News.
As bioprocessors face rising solvent costs, supply-chain disruptions, and mounting sustainability demands, solvent-recovery systems are emerging as strategic investments that reduce operating expenses, strengthen production resilience, and help companies meet increasingly ambitious environmental goals.
The post Solvent Recovery Gains Ground in Bioprocessing appeared first on GEN - Genetic Engineering and Biotechnology News.
When cells enter senescence, they begin releasing signals that contribute to chronic inflammation. Researchers have now pinpointed R-loops as a key component to modulating these inflammatory signals.
The post Age-Related Inflammation Linked to R-Loop Nucleic Acids, Opens Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
The collaboration, launched through a multi-target discovery collaboration and license agreement, is designed to combine Merck’s global expertise in discovering novel therapeutics with Protillion’s Prot-MaP™ on-chip antibody discovery platform, short for Protein Display on a Massively Parallel Array.
The post Merck, Protillion Launch AI Drug Discovery Collaboration with Up-to-$510M in Milestone Payments appeared first on GEN - Genetic Engineering and Biotechnology News.
KRAS‑mutant pancreatic cancer relies on caspase‑8 to evade necroptosis, according to a new study. Blocking caspase‑8 triggers cell death in mouse models and patient‑derived organoids, revealing a promising therapeutic vulnerability.
The post Pancreatic Cancer Cell Death Triggered by Caspase‑8 Blockade in Preclinical Models appeared first on GEN - Genetic Engineering and Biotechnology News.
The conference emphasized that future competitive advantage in biomanufacturing will come less from building additional capacity and more from increasing productivity, speed, and process intelligence across the development-to-manufacturing workflow.
The post Six Takeaways from the Danaher Bioprocessing Summit appeared first on GEN - Genetic Engineering and Biotechnology News.
In a detailed cellular study of Crohn’s disease, researchers mapped how gene activity changes across more than 50 cell types in the gut and created an open resource, IBDverse, characterizing each cell type and those whose activity shifts in disease.
The post Single-Cell RNA Sequencing Reveals Gene Activity Changes in Crohn’s Disease appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers developed ResMap, a community resource providing both a standardized experimental framework and quantitative dataset for systematic comparison of persister cell vulnerabilities across cancer contexts.
The post Therapy-Resistant Residual Cancer Cell Dependencies Mapped appeared first on GEN - Genetic Engineering and Biotechnology News.
Ultrasmall silica nanoparticles induce ferroptosis and reshape the prostate tumor microenvironment, reversing myeloid suppression and boosting responses to checkpoint blockade.
The post Silica Nanoparticles Induce Ferroptosis, Reprogram Immunity in Prostate Cancer Models appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN webinar, our speakers will examine five common planning gaps that can contribute to bottlenecks, including single-source material dependency, raw material pack size selection, sensitive buffer designs, and single-use systems designed without realistic failure modes.
The post When Process Design Fails: 5 Common Planning Gaps That Create Downstream Purification Bottlenecks appeared first on GEN - Genetic Engineering and Biotechnology News.
Moderna’s investigational mRNA flu vaccine generated broader, longer-lasting immune responses than a standard flu shot, potentially improving protection against evolving influenza strains and reducing vaccine mismatch.
The post mRNA Flu Vaccine Shows Stronger, Longer-Lasting Immune Response appeared first on GEN - Genetic Engineering and Biotechnology News.
ZoBio maintains that unlike transactional DEL screening approaches that focus solely on hit generation, its platform is designed to deliver biologically relevant, structurally characterized hit matter with clear potential for progression.
The post ZoBio Introduces DNA-Encoded Library Service for Exploratory Drug Discovery Programs appeared first on GEN - Genetic Engineering and Biotechnology News.
Deep learning unveils how drugs affect the dynamics of key structures within the cell. A new study maps condensate morphology to functional outcomes and sheds light on markers of health.
The post AI Predicts Gene Regulation for Drug Discovery Using Condensate Morphology appeared first on GEN - Genetic Engineering and Biotechnology News.
Parabilis’ IPO surpasses the $625 million IPO carried out in April by Kailera Therapeutics, which topped the previous record-high among U.S. biotechs, the $604 million offering of Moderna in December 2018, two years before the messenger RNA (mRNA) vaccine developer won FDA emergency authorization for its COVID-19 vaccine.
The post StockWatch: Parabilis Medicines Makes Wall Street History with $770.5M IPO appeared first on GEN - Genetic Engineering and Biotechnology News.
A study has shown that collagen exists inside cells as a liquid-like droplet rather than as a long, rigid rod-like structure, and outline a “liquid extrusion” hypothesis for collagen export that may have implications for wound healing, fibrosis, and cancer.
The post Collagen Resides Inside Cells in Liquid Condensate-Like Form appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers at The University of Texas Medical Branch developed a single-dose mRNA vaccine that provided complete protection against the deadly Andes hantavirus infection in animal tests, potentially offering a rapid-response tool for future outbreaks.
The post Hantavirus One-Shot mRNA Vaccine Fully Protects in Syrian Hamster Model appeared first on GEN - Genetic Engineering and Biotechnology News.
The company's proprietary platform combines an ultrasound-mediated delivery technology with payload engineering capabilities that support the development of DNA and RNA therapeutics, gene editing, and gene silencing approaches.
The post SonoThera Raises $125M to Develop Ultrasound-Mediated Genetic Medicines appeared first on GEN - Genetic Engineering and Biotechnology News.
Installed in a custom Titan Krios, the laser phase plate boosts small‑protein cryo‑EM by enhancing motion correction, early‑frame recovery, particle visualization, and 3D classification and alignment.
The post Laser‑Driven Phase Contrast Enhances Cryo‑EM Resolution of Small Proteins appeared first on GEN - Genetic Engineering and Biotechnology News.
A GWAS carried out in a genetically diverse population of rats identified genetic markers associated with compulsive cocaine use, and uncovered a potential new therapeutic target in the liver.
The post Potential Cocaine Addiction Targets Identified Through Genetic Mapping in Rats appeared first on GEN - Genetic Engineering and Biotechnology News.
Engineered extracellular vesicles that deliver full-length DMD mRNA to skeletal muscle restored dystrophin production and significantly improved muscle strength and function in Duchenne muscular dystrophy models without notable toxicity.
The post New mRNA Delivery Platform Restores Muscle Function in DMD Models appeared first on GEN - Genetic Engineering and Biotechnology News.
Antimicrobial resistance is a serious healthcare issue affecting the world and needs to be taken seriously. Unfortunately, the development of antibiotics is slow and mostly unsuccessful. A new approach is required.
The post Fighting Antimicrobial Resistance with Biomaterials and Phages appeared first on GEN - Genetic Engineering and Biotechnology News.
Nuvalent’s pipeline is headed by the ROS1 inhibitor zidesamtinib (NVL-520) and the ALK inhibitor eladalkib (NVL-655), which according to the company represent potential best-in-class, next-generation, highly selective treatments for NSCLC. Both are brain penetrant. The FDA has set target decision dates of September 18 for zidesamtinib and November 27 for neladalkib.
The post GSK to Acquire Nuvalent for $10.6B, Boosting Cancer Pipeline with Precision NSCLC Treatments appeared first on GEN - Genetic Engineering and Biotechnology News.
The study challenges the idea that cellular complexity emerged from a single evolutionary encounter, and point instead to a gradual process of interactions among bacteria and giant viruses lasting millions of years.
The post Origins of First Eukaryotes Linked to Contributions from Multiple Bacteria and Giant Viruses appeared first on GEN - Genetic Engineering and Biotechnology News.
Findings from a new study suggest that macrophage accumulation and smooth muscle cell loss may contribute to brain aneurysm rupture, identifying potential markers that could help predict rupture risk and prevent stroke.
The post Brain Aneurysm Study Identifies Structural, Immune Markers of Rupture Risk appeared first on GEN - Genetic Engineering and Biotechnology News.
While Symeres is known for its drug discovery expertise, the expanded capability via spray drying further strengthens its ability to support complex molecules through development and into the clinic.
The post Symeres Expands Spray Drying Capabilities at Its U.S. New Jersey Site appeared first on GEN - Genetic Engineering and Biotechnology News.
Augmenting experiments with in silico tools can help improve manufacturability and boost yields, says an AI technology company, in a conference debate about opportunities, challenges, and hopes for the future.
The post <i>In Silico</i> Devices May Improve Drug Manufacturability appeared first on GEN - Genetic Engineering and Biotechnology News.
A gorilla adenovirus originally developed for vaccines is showing unexpected promise as a cancer therapy—one whose therapeutic properties may be baked into its native biology rather than engineered in.
The post Gorilla Adenovirus Brings Natural Edge to Cancer Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.
New nucleic acid amplification technique provides both species breadth and sensitivity for Mycoplasma detection in biologics, making it viable for in-process control and release testing.
The post Updated Amplification Tool Rapidly Detects <i>Mycoplasma</i> appeared first on GEN - Genetic Engineering and Biotechnology News.
This report is intended to inform discussion and decision making, not to prescribe solutions. Produced in collaboration with GEN, it reflects the collective voice of an industry adapting to new scientific and regulatory realities.
The post The State of Biologics Testing 2026 appeared first on GEN - Genetic Engineering and Biotechnology News.
T‑cell synapse remodeling depends on actin dynamics via the PTPN22–PSTPIP1 axis. Understanding this axis could inform both autoimmune research and efforts to modulate T‑cell activation in cancer immunotherapy.
The post T-Cell Synapse Formation Is Restrained by PTPN22–PSTPIP1 Signaling appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers reported promising interim results from a Phase I clinical trial testing a new dual vaccine against Lassa fever and rabies.
The post First-in-Human Trial Reports Promising Dual Lassa–Rabies Vaccine Data appeared first on GEN - Genetic Engineering and Biotechnology News.
Vega’s lead candidate VGA039 could, if approved, be the first subcutaneous prophylactic therapy with a more convenient once-monthly, self-administered dosing regimen for patients with VWD, compared with current therapies requiring more frequent (2-3x/week) intravenous infusions.
The post Incyte to Acquire Vega Therapeutics for Up-to-$2B, Growing Hematology Pipeline with Phase III VWD Candidate appeared first on GEN - Genetic Engineering and Biotechnology News.
Growing interest in in vivo cell and gene therapies is driving significant investment, given their potential to address some of the manufacturing and commercialization challenges associated with current ex vivo approaches.
The post Fifteenth <i>In Vivo</i> Lentiviral Vector-Based Therapeutic Technology Added to VIVEbiotech’s CGT Platform appeared first on GEN - Genetic Engineering and Biotechnology News.
A complete wiring diagram of all the connections between the fruit fly brain and "spinal cord" provides translational applications to humans. The map is available open-source to propel research of the nervous system.
The post Complete Connectome of Fruit Fly Central Nervous System Now Open-Source appeared first on GEN - Genetic Engineering and Biotechnology News.
Studying blood samples from people living with HIV researchers found that most persistent cases of detectable viremia among those on long-term ART are due to defective, noninfectious copies of viral RNA.
The post Defective HIV RNA Linked to Persistent Viremia During Long-Term ART appeared first on GEN - Genetic Engineering and Biotechnology News.
AI‑guided protein design was applied to turn caffeine into a reversible molecular off‑switch for engineered cells, enabling tunable control of gene circuits, pyroptosis, and CAR T cell activity.
The post AI Reimagines Caffeine as a Molecular Off‑Switch for Engineered Cells appeared first on GEN - Genetic Engineering and Biotechnology News.
ACT-CHIK is an EU-funded project (roughly $17 million) led by Institut Pasteur that will advance chikungunya vaccine trials across four African countries and prepare local manufacturing, strengthening vaccine access, outbreak preparedness, and regional production capacity.
The post Chikungunya Vaccine Development in Africa Accelerated by ACT-CHIK appeared first on GEN - Genetic Engineering and Biotechnology News.
CiteSentinel was designed to give attorneys a fast and easy way to confirm that every citation in a filing corresponds to a real case, a real statute, and a real legal authority.
The post CiteSentinel Launched to Detect and Prevent AI Hallucinations in Legal Citations appeared first on GEN - Genetic Engineering and Biotechnology News.
“Guardian of the genome,” p53 is now therapeutically accessible using CRISPR-based technology from Jennifer Doudna’s lab. The approach uses RNA signatures to identify and destroy traditionally undruggable cancer cells.
The post CRISPR Shreds Undruggable Cancer Cells with Precision appeared first on GEN - Genetic Engineering and Biotechnology News.
Abivax’s stock plummeted after analysts from Jefferies, Morgan Stanley, Truist Securities, and Wedbush Securities raised as a safety concern a portion of data showing malignancies in nine patients among the 580 enrolled in the study. Jefferies reacted the strongest among the firms, downgrading Abivax’s stock rating from “Buy” to “Hold” and lowering its 12-month price target on the company’s shares 44%, from $160 to $90.
The post StockWatch: Abivax Survives a Roller Coaster Week appeared first on GEN - Genetic Engineering and Biotechnology News.
By tracking thousands of B cells across more than 100 germinal centers in mice, researchers revealed how the system produces highly effective antibodies, challenging the idea that antibody improvement is driven mainly by rare growth “bursts” among the most successful B cells.
The post How Germinal Centers Generate Antibodies Through Noisy Rounds of Mutation and Selection appeared first on GEN - Genetic Engineering and Biotechnology News.
TRIM, an integrated genome engineering platform that combines prime editing, gene knockouts, and large-scale chromosome engineering, enabled efficient stacking of multiple beneficial traits to accelerate precision breeding in monocot crops.
The post Twin Prime Editing Enables Rapid Trait Stacking in Crops appeared first on GEN - Genetic Engineering and Biotechnology News.
The workflow pairs Bio-Techne’s MauriceFlex imaged capillary isoelectric focusing fractionation system with Refeyn's TwoMP mass photometry platform to connect charge heterogeneity with molecular weight and aggregation at single‑molecule resolution.
The post Bio-Techne, Refeyn Partner on Workflow for Bispecific Antibody, Biosimilar Characterization appeared first on GEN - Genetic Engineering and Biotechnology News.
In this episode of GEN's Touching Base, editors discuss a variety of news including the halt of a lead pipeline program at Fulcrum Therapeutics, a new multibillion dollar collab, protein modeling updates from Biohub, and new potential for vaccine development.
The post A Billion-Dollar Deal, Trial Trouble, Biohub Updates, and Vaccine Research News appeared first on GEN - Genetic Engineering and Biotechnology News.
The partnership’s first phase will see a review of the current medicines landscape conducted to identify opportunities for innovation. This information will be used to find systemic gaps in brain-entry technologies.
The post Brain-Targeted Drug Discovery Barriers Drive Deep Science Ventures and Medicines Discovery Catapult Deal appeared first on GEN - Genetic Engineering and Biotechnology News.
D&D‑seq uses a base editor–nanobody fusion to record DNA–protein contacts at single‑cell resolution. The method maps transcription factor and chromatin-remodeling proteins.
The post D&D‑seq Uses Base Editing to Map DNA–Protein Interactions in Single Cells appeared first on GEN - Genetic Engineering and Biotechnology News.
Scientists defined a previously undescribed cellular mechanism for fighting pathogens—which they called “antibody-directed xenophagy”—through which cells tag for digestion antibody-coated bacteria and viruses that cross the cell membrane.
The post Novel Intracellular Pathway Identified That Protects Against Viral and Bacterial Infection appeared first on GEN - Genetic Engineering and Biotechnology News.
Experts urge lawmakers to mandate screening, customer verification, and recordkeeping for synthetic DNA orders and synthesis equipment to strengthen biosecurity as advancing AI lowers barriers to creating biological threats.
The post Open Letter: In Support of Mandatory Nucleic Acid Synthesis Screening and Recordkeeping appeared first on GEN - Genetic Engineering and Biotechnology News.
New findings suggest that pairing an experimental vaccine adjuvant with injectable polio vaccines can induce a robust immune response in the gastrointestinal tract, potentially reducing virus transmission and supporting global eradication efforts.
The post Experimental Adjuvant Could Strengthen Mucosal Immunity with Injectable Polio Vaccines appeared first on GEN - Genetic Engineering and Biotechnology News.
This collaboration between Stipple Bio and Lonza combines the former’s epitope discovery capabilities with the latter’s GlycoConnect antibody conjugation technology, HydraSpace polar spacer technology, and a toxSYN linker payload.
The post Stipple Bio and Lonza Agree to Focus on Advancing Oncology ADC Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers engineered a human hookworm to produce an anti-tetrodotoxin antibody, which the parasite secreted into the bloodstream of a preclinical host animal, and which studies showed partially neutralized the toxin.
The post Human Hookworm Engineered to Produce, Secrete Anti-Tetrodotoxin Antibody Into Preclinical Host Bloodstream appeared first on GEN - Genetic Engineering and Biotechnology News.
Behind the expansion of their collaboration, Incyte and Genesis say, is the promise shown so far by the two initial targets, both selected by Incyte as called for in the initial strategic collaboration. One is a “very hard-to-drug, novel target” for which the companies worked to create novel, first-in-class chemical matter, while the other is a target that other companies have sought to make druggable without success, Pablo J. Cagnoni, MD, Incyte’s president and global head of R&D, told GEN.
The post Small Molecules to Big Partnership: Incyte, Genesis Expand AI Collaboration to $1B+ appeared first on GEN - Genetic Engineering and Biotechnology News.
As TSC-101 is advanced toward a pivotal trial, which is expected to begin later this year, Cellares’ manufacturing platform is being evaluated as a scalable and economical path to future demand.
The post Cellares and TScan Agree to Evaluate Automated Manufacturing TSC-101 for Patients with Hematologic Malignancies appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers discovered manikomycin, a novel antibiotic that kills drug-resistant bacteria by targeting a previously unknown ribosomal vulnerability. The breakthrough could lead to a new class of treatments against antimicrobial resistant bacteria.
The post New Antibiotic, Manikomycin, Acts on Novel Ribosomal Target appeared first on GEN - Genetic Engineering and Biotechnology News.
The global biopharma industry is placing increasing importance on regional support rather than only centralized expertise to help complex programs advance. A key benefit is access to local expertise in or near their time zone.
The post Bioproduction Pivots from Centralized to Regional Support appeared first on GEN - Genetic Engineering and Biotechnology News.
As cell therapy developers push toward commercial-scale manufacturing, bioprocessing experts rethink how hematopoietic stem cells are isolated. Emerging buoyancy-based technologies promise higher yields, gentler handling, and scalable workflows that could reshape production of next-generation regenerative medicines.
The post Gentler Cell Separation Methods Gain Momentum appeared first on GEN - Genetic Engineering and Biotechnology News.
A web app for analyzing antibody structure could help drug manufacturers assess the developability of their products, say researchers who have developed the therapeutic antibody profiler (TAP) and other software.
The post Web App Helps Flag Antibodies Where Manufacturability Might Be an Issue appeared first on GEN - Genetic Engineering and Biotechnology News.
Improved viral vector production and an AI-ready workforce are the future of the drug industry, according to NIIMBL, which has selected several AAV and AI-focused projects for support.
The post NIIMBL to Support Vector Production and AI-Ready Training Projects appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN webinar, Erdinc Sezgin, PhD, Karolinska Institutet, will present how his lab profiled plasma membrane order across 12 immune cell subtypes simultaneously in healthy donors and patients with long COVID and chronic lymphocytic leukemia.
The post Immune Cell Phenotyping: Cell Surface Architecture Informs Disease Biology appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers have uncovered a previously underappreciated mechanism, where RNA splicing plays a central role in shaping immune response. The results provide insights into immune-mediated diseases, such as rheumatoid arthritis and lupus.
The post Immune Response Activated by RNA Splicing Opens Targeted Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
