Researchers reversed certain behavioral symptoms in a 16p11.2 deletion mouse model of autism spectrum disorder by activating the P2Y2 receptor in endothelial cells of brain blood vessels, which increased blood flow in the brain.
The post Autism Target Discovered in Endothelial Cells in Genetic Deletion Mouse Model appeared first on GEN - Genetic Engineering and Biotechnology News.
The strongest binder from a primary screen is not necessarily the best drug starting point. Peptide discovery campaigns should capture molecular architecture, biological context, time, and developability from the outset.
The post Designing Peptide Screens to Generate Knowledge, Not Just Hits appeared first on GEN - Genetic Engineering and Biotechnology News.
New research reveals how MRSA exploits the kidney’s hyperosmotic inner medulla to evade immune defenses, establish a persistent reservoir, and spread, while suggesting potential therapeutic strategies to limit infection.
The post MRSA Exploits Kidney’s Inner Environment to Persist and Spread appeared first on GEN - Genetic Engineering and Biotechnology News.
This pathway, which the authors dub the “BACH2-NRF2 axis,” is independent of the well-known BCL11A transcription regulator, the target of the approved cell therapy Casgevy for sickle cell disease (SCD).
The post Genome-Wide Analysis Identifies BACH2 as Potential Fetal Hemoglobin Activation Target appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN webinar, Joseph Shultz (VP of technical development and manufacturing, Ottimo Pharma) and Imroz Ghangas (VP of commercial sales, Asimov) discuss strategies for achieving high-performing clonal titers and advancing a dual-paratopic cancer immunotherapy from sequence to dosed patient in under a year.
The post Advancing Brain Organoids from Research Models to Scalable Platforms appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers analyzing pre-treatment stool samples from 1,364 cancer patients across cancer types, stages, and treatments discovered that adults aged 50 years or younger with colorectal and breast cancers have distinct gut microbiome patterns compared with individuals diagnosed later in life.
The post Microbiome Patterns Vary Among Individuals with Different Cancer Types and Onset Age appeared first on GEN - Genetic Engineering and Biotechnology News.
High-throughput proteomics combined with AI-based structural modeling helped researchers discover molecular glues that degrade VAV1. The approach could support new therapies for blood cancers and autoimmune diseases.
The post AI and Proteomics Accelerate VAV1 Molecular Glue Discovery appeared first on GEN - Genetic Engineering and Biotechnology News.
Merck agreed to pay SciBrunch up to $2.13 billion consisting of $400 million upfront and the remainder in payments tied to achieving milestones across multiple indications.
The post Merck, SciBrunch Launch Up-to-$2.13B Collaboration to Develop Preclinical KRAS-Inhibiting Molecular Glue appeared first on GEN - Genetic Engineering and Biotechnology News.
The consortium aims to address antibody development bottlenecks by creating standardized datasets and AI models that support earlier risk detection and more informed candidate selection.
The post Ginkgo Datapoints, Apheris Announce Founding Members of Antibody Developability Consortium appeared first on GEN - Genetic Engineering and Biotechnology News.
Chemotherapies frequently cause cancer cells to enter senescence, but do not fully eliminate these cells. Therefore, it is useful to target these therapy-induced senescent cells with senolytics that eliminate them.
The post How Cells Respond Differently to a Cancer-Causing Gene appeared first on GEN - Genetic Engineering and Biotechnology News.
Predictive cell intelligence can be used to reveal cellular states and emerging cellular trajectories earlier in the manufacturing process and to support more informed bioprocessing decisions.
The post Current Challenges in CAR T Manufacturing appeared first on GEN - Genetic Engineering and Biotechnology News.
AI-assisted genomic analysis was combined with human genetics and fruit fly experiments to link reduced BRSK1 function to a variable neurodevelopmental disorder.
The post AI Tool Helps Link <i>BRSK1</i> Variants to Neurodevelopmental Disorder appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers developed a potential antibody-based approach to reducing neurodegeneration in tauopathies, with studies showing that in a mouse Alzheimer’s model anti-CXCR3-treated animals retained more brain tissue and had better memory, even though tau levels stayed the same.
The post Antibody Blocks T Cell Infiltration and Limits Neurodegeneration in Alzheimer’s Mice appeared first on GEN - Genetic Engineering and Biotechnology News.
The research may be useful for the development of DNA-based therapeutics and gene-delivery systems. Packaging genetic material into structures that restrict nuclease access could potentially increase its resistance to degradation.
The post Scientists Observe Enzymes Breaking Down DNA in Real Time appeared first on GEN - Genetic Engineering and Biotechnology News.
Adding a viral protein, NoV B2, helped self-amplifying RNA overcome cellular defenses and produce more target protein without diminishing immune stimulation, potentially enabling future vaccines to use lower doses.
The post Viral Protein Helps Self-Amplifying RNA Overcome Cellular Defenses appeared first on GEN - Genetic Engineering and Biotechnology News.
This past week, Nektar Therapeutics (Nasdaq: NKTR) offered an uncommon example of victory in court translating into defeat on Wall Street. Nektar’s shares finished Friday flat, dipping 4% from $59.38 to $57.06 despite a jury siding with the San Francisco biotech over Eli Lilly (NYSE: LLY) in a three-year-old legal dispute over the pharma giant’s terminating a collaboration agreement to co-develop Nektar’s lead pipeline candidate rezpegaldesleukin (rezpeg).
The post StockWatch: Nektar Shares Flat as $90M Jury Verdict Less than Sought in Lilly Suit appeared first on GEN - Genetic Engineering and Biotechnology News.
SFC is a platform technology that utilizes upcycled CO2 for the purification of natural and synthetic molecules that is both highly efficient and sustainable at the same time.
The post Thar Process Partners with ExtrateX to Bring Prep to Process-Scale SFC to Europe appeared first on GEN - Genetic Engineering and Biotechnology News.
A new study finds the drug OM-89 may help bladder cells eliminate hidden E. coli by activating lysosomal pathways and increasing antibiotic uptake, potentially reducing bacterial regrowth in recurrent UTIs.
The post How Bladder Cells Fight Hidden <i>E. coli</i>: New Insights Into Recurrent UTIs appeared first on GEN - Genetic Engineering and Biotechnology News.
A study in mouse and human models showed how stroke promotes glioma growth by remodeling the tumor microenvironment, with the emergence of a distinct population of tumor-associated astrocytes with reduced Ca2+ activity, and enrichment of tumor-associated microglia and macrophages (TAMs).
The post Stroke Remodels Tumor Microenvironment to Promote Glioma Growth appeared first on GEN - Genetic Engineering and Biotechnology News.
A CRISPR-based method for disrupting genes across bacteriophage genomes has been developed, creating a faster route to uncover gene functions and engineer phages for potential therapeutic and biotechnology applications.
The post New CRISPR-Based Tool Enables Genome-Wide Mutagenesis of Bacteriophages appeared first on GEN - Genetic Engineering and Biotechnology News.
Two studies reveal how APOE4, a major genetic risk factor for Alzheimer’s, disrupts brain blood vessels and promotes abnormal protein accumulation, pointing to potentially reversible disease mechanisms.
The post APOE4 Linked to Potentially Reversible Mechanisms of Brain Blood Vessel Damage in Alzheimer’s appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers captured the first high-resolution 3D images of the muscle cell calcium channel RyR1 at six stages of opening inside the intact sarcoplasmic reticulum membrane, potentially helping to explain mechanisms behind certain muscle diseases.
The post Muscle Cell Calcium Channel Structure, Synchronicity Could Advance Muscle Disease Therapeutics appeared first on GEN - Genetic Engineering and Biotechnology News.
JNC is using BioProcess International 2026 to spotlight Cellufine and its emerging MLP chromatography media, developed to address purification challenges posed by viral vectors, vaccines, and other increasingly large and complex biological products.
The post JNC Targets Bigger Molecules with Cellufine appeared first on GEN - Genetic Engineering and Biotechnology News.
Process intensification and the adoption of continuous-mode manufacturing has increased the consumption of culture media. Managing these ever-growing culture volumes in a cost and space efficient manner has become a major challenge for drug manufacturers, says Just – Evotec Biologics.
The post Intense Media Pressure an Emerging Challenge in CHO Business appeared first on GEN - Genetic Engineering and Biotechnology News.
The company’s Quality Risk Management framework enabled proactive identification of compliance risks, reduced uncertainties associated with cross-regional technology transfer, and provided greater predictability as therapies advance toward regulatory submission and commercialization.
The post Altruist Biologics’ Suzhou Site Receives EMA GMP Certification appeared first on GEN - Genetic Engineering and Biotechnology News.
A slow-release liposome system delivered local anesthesia for weeks in rats, potentially enabling longer-lasting nerve blocks and new approaches to pain management.
The post New Liposome Design Could Provide Effective Slow-Release Drug Delivery System appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers trained an AI model to learn chemical patterns associated with stability in drug-like molecules and accurately predict where their hydrogen atoms should be positioned.
The post Tautomer-Predictor AI Tool Identifies Stable Molecules for Drug Discovery appeared first on GEN - Genetic Engineering and Biotechnology News.
The collaboration pairs the Genialis Supermodel with Inventia Life Science’s RASTRUM 3D cell model platform to test therapeutic hypotheses in models that mirror the tumor biology of specific patient groups.
The post Genialis and Inventia Life Science Collaborate to Link Patient Biology with 3D Pancreatic Cancer Models appeared first on GEN - Genetic Engineering and Biotechnology News.
AI-augmented digital twins that merely report, rather than control processes, could help biotechnology companies untangle the complexities of analyzing big multidimensional nonlinear datasets to help simplify and improve process intensification.
The post Digital Shadows to Aid Complexity in Handling Process Intensification appeared first on GEN - Genetic Engineering and Biotechnology News.
A novel media cleaning process could help drug companies significantly reduce production costs, according to MIT researchers, who say the approach could improve the economic case for perfusion bioreactors and continuous manufacturing processes.
The post Media Cleaning Could Help Biopharma Cut Costs and Fully Embrace Perfusion appeared first on GEN - Genetic Engineering and Biotechnology News.
According to Basecamp, EDEN offers the ability to design long and complex DNA sequences with large serine recombinases capable of delivering those sequences precisely.
The post Anthropic-, Nvidia-Backed Basecamp Research Raise $140M Series C Financing Toward Advancing AI-Designed Drugs appeared first on GEN - Genetic Engineering and Biotechnology News.
A biomimetic nanoparticle platform inspired by photosynthesis helped activate surviving retinal nerve cells in mice with advanced retinal degeneration.
The post Biomimetic Nanoparticles Trigger Light Responses in Blind Mouse Retinas appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers combined Raman microscopy with gene expression data at single-cell resolution from the same cells, and AI, to develop RamanOmics, a noninvasive way to detect biomarkers of cellular senescence as “barcodes."
The post Cell Senescence ‘Barcodes’ Identified with Raman Microscopy and Gene Expression Data appeared first on GEN - Genetic Engineering and Biotechnology News.
The collaboration between Syngene and Bristol Myers Squibb began in 1998, culminating in the establishment of the Biocon Bristol Myers Squibb Research and Development Center, Syngene's first dedicated R&D Center.
The post Syngene Expands Integrated Drug Development and Manufacturing Services with BMS appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN Learning Lab, our expert panelists Guangping Gao, PhD, and Thomas Quinn will explore critical steps in the AAV workflow that influence vector quality and downstream experimental success.
The post Advancing AAV Development: From Production to Performance appeared first on GEN - Genetic Engineering and Biotechnology News.
Despite advances in other proteomic methods, including mass spectrometry, western blotting remains one of the most widely-used techniques across life sciences research due to its affordability, specificity, and widespread accessibility.
The post Best Practices for Establishing Data Integrity in Western Blotting appeared first on GEN - Genetic Engineering and Biotechnology News.
The SARS-CoV-2 protein ORF8 reprograms macrophages to promote viral replication and lung inflammation. Blocking the ORF8-linked receptor IL-17RA reduced inflammation and fibrosis in mice, pointing to a potential therapeutic target.
The post SARS-CoV-2 Protein Fuels Lung Inflammation by Hijacking Macrophages appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN webinar, our expert speaker Joshua Michael Hare, MD, will examine how therapeutically relevant research is helping shape the development of cell therapies for cardiovascular disease.
The post Advancing Cell Therapy for Cardiovascular Disease appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN webinar, our expert speakers will discuss the latest trends, challenges, and innovations shaping fluid transfer and freeze-thaw workflows.
The post Emerging Trends in Fluid Transfers and Freeze-Thaw Workflows appeared first on GEN - Genetic Engineering and Biotechnology News.
Novo said it planned to launch “more than five multi-blockbusters” or drugs with multiple billions of dollars in sales every year through 2030, and generate more than DKK 150 billion (just over $23 billion) in risk-adjusted pipeline sales by 2035.
The post StockWatch: Novo’s 2030 Strategy Underwhelms Investors at Capital Markets Day appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers identified genes that enable the regeneration of dopamine-producing neurons in planarians. This provides a roadmap for investigating whether similar pathways can be activated in humans and potentially leveraged to treat traumatic brain injuries and neurodegenerative diseases.
The post Genes Involved in Flatworm Brain Regeneration Identified appeared first on GEN - Genetic Engineering and Biotechnology News.
Australia is closely monitoring the H5N1 influenza strain after detections in sea lions, seals, dolphins, and foxes, prompting surveillance for mammal adaptation while authorities report low human health risk.
The post H5N1 Spreads Among Australian Wildlife as Flu Season Ramps Up appeared first on GEN - Genetic Engineering and Biotechnology News.
Mayo Clinic recently launched Precure with founding partner Thermo Fisher Scientific to help transform how the life sciences community understands the biological changes that occur as disease develops before symptoms occur.
The post Precure Selects Helix as Multiomics Lab and AI Tools Provider appeared first on GEN - Genetic Engineering and Biotechnology News.
Sanfilippo syndrome type A (MPS IIIA) is a rare, fatal lysosomal storage disease that primarily affects the central nervous system and is marked by rapid neurodegeneration beginning in early childhood.
The post Andelyn Curator Biomanufacturing Platform Supports Fayuvi Gene Therapy Approval appeared first on GEN - Genetic Engineering and Biotechnology News.
Brenipatide showed a mean half-life ranging between 9.08 days and 12.5 days, with the longer half-life seen in participants given the highest dose of the drug at 4.5 mg.
The post Lilly’s GIP/GLP-1 Candidate Brenipatide Shows Early Clinical Promise in Substance, Psych Disorders appeared first on GEN - Genetic Engineering and Biotechnology News.
A 12-week pilot study found time-restricted eating was safe and feasible for people with early Huntington’s disease, with improvements in disease severity, neurofilament light, and mitochondrial function.
The post Time-Restricted Eating Linked to Improved Huntington’s Disease Markers appeared first on GEN - Genetic Engineering and Biotechnology News.
The instrument, the first benchtop-scale platform in Asahi Kasei Bioprocess’s VANTIJ family, extends the automation and operator-focused design principles of the existing portfolio while simplifying virus filtration processes.
The post Asahi Kasei Introduces VANTIJ<sup>®</sup> SU-VFC Benchtop Virus-Filtration System appeared first on GEN - Genetic Engineering and Biotechnology News.
Many early-stage drug developers need a more efficient path to obtaining the GMP material required to reach the clinic. SmartScale was designed to help close that gap.
The post GBI Biomanufacturing Set to Launch SmartScale GMP Solutions appeared first on GEN - Genetic Engineering and Biotechnology News.
Nu-Tek BioSciences will use BPI East to highlight animal-origin-free peptones and hydrolysates designed to strengthen media consistency, reduce raw-material risk, and support more reliable cell culture and fermentation processes for biologics manufacturers.
The post Nu-Tek Brings Topic of Raw-Material Risk to BPI appeared first on GEN - Genetic Engineering and Biotechnology News.
Spectroscopic analysis techniques rely on empirical models that are time consuming and expensive to make. Biopharma companies could speed development and reduce costs using a model-free measuring approach called pure-component analysis, says Nirrin Technologies.
The post Model-Free, Pure Component Analysis Could Help Biopharma Cut Costs appeared first on GEN - Genetic Engineering and Biotechnology News.
In his new book Curved Air, Kevin Davies, PhD, portrays the fascinating story of sickle cell disease, from its origins in sub-Saharan Africa to advances in gene therapy, along with powerful personal insights from patients, including some who are finally living pain-free.
The post The Saga of Sickle Cell Disease appeared first on GEN - Genetic Engineering and Biotechnology News.
Research suggests that the brain is two distinct organs that evolved independently and comprise two ancient nervous systems packaged together; a hindbrain that regulates essential functions, and a forebrain that handles higher level thinking.
The post Two-Organ View of the Human Brain Emerges appeared first on GEN - Genetic Engineering and Biotechnology News.
Backed by preclinical data and funding from The Michael J. Fox Foundation, Ariadne Bio is advancing AB-300, a serotonin 2A receptor agonist, as a potential treatment for Parkinson’s-related apathy.
The post Palomar Labs Spins Out Ariadne Bio to Advance Non-Hallucinogenic Therapy for Parkinson’s Apathy appeared first on GEN - Genetic Engineering and Biotechnology News.
In kidney organoids, elevated glucose triggered tissue-intrinsic inflammation and epithelial cell detachment without overt cytotoxicity. Inhibiting MIF, TNF-alpha, or MAPK-related signaling helped protect the organoids, suggesting inflammatory pathways may be targetable in diabetic kidney disease.
The post Kidney Organoids Reveal Inflammatory Drivers of Diabetic Kidney Disease appeared first on GEN - Genetic Engineering and Biotechnology News.
Validated on the CellXpress.ai automated cell culture system, the new workflow combines organoid biology expertise and laboratory automation to help researchers reduce variability, expand scale, and move discoveries toward impact with more confidence.
The post Molecular Devices and STEMCELL Technologies Team Up to Automate Organoid Research appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers carrying out multiomics analyses of tumors from high-grade glioma patients found distinct molecular profiles and survival outcomes in different age groups and according to sex, and identified candidate treatment targets and potential prognostic markers.
The post High-Grade Glioma Biology Varies by Age and Sex, Revealing Potential Treatment Targets appeared first on GEN - Genetic Engineering and Biotechnology News.
Officials at Sartorius and the NIBRT said their partnership will strengthen global workforce readiness and accelerate the industry transition toward more efficient and sustainable biopharmaceutical production.
The post Sartorius and NIBRT Partner on Intensified and Continuous Bioprocessing Training Center appeared first on GEN - Genetic Engineering and Biotechnology News.
Mithrl’s platform embeds its biomedical world model and AI agents within biopharma companies’ own environments, providing the context and orchestration needed to apply frontier AI to proprietary data and pipelines.
The post Mithrl Raises $20M to Expand Deployment of Its Biomedical World Model Across Biopharma appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers identified a brain protein, NSF, that is important for maintaining dopamine-related cells and normal development, providing new insights into ADHD and potential therapeutic strategies.
The post Brain Protein in Mice Offers Insights Into Brain Development and ADHD appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers developed a prophylactic phage therapy targeting Salmonella enterica Typhimurium that in mouse models colonized the gut, and produced lytic phages that protected against future infection by the pathogen, improving survival.
The post Prophylactic Phage Therapy Protects Mice Against Oral <i>Salmonella</i> Infection appeared first on GEN - Genetic Engineering and Biotechnology News.
The partnership marks Cellares’ first collaboration with a cell therapy developer in Asia and will evaluate automated manufacturing of GenomeFrontier’s virus-free CAR T process for clinical manufacturing in the U.S.
The post Cellares and GenomeFrontier Therapeutics Partner to Advance Automated Manufacturing of GF-CART01 appeared first on GEN - Genetic Engineering and Biotechnology News.
A new genome-editing method, prime assembly, precisely inserts long DNA sequences into targeted genomic locations, potentially enabling mutation-agnostic gene therapies for diverse genetic diseases with fewer individualized edits.
The post Prime Assembly Expands Genome Editing with Precise, Large-Scale DNA Integration appeared first on GEN - Genetic Engineering and Biotechnology News.
Scientists in New Delhi found that red light dramatically boosted lipstatin production in Streptomyces, while reshaping its growth. The work points to illumination as a simple, non-invasive lever for improving yields in microbial biomanufacturing.
The post Red Light Supercharges Anti-Obesity Drug Precursor appeared first on GEN - Genetic Engineering and Biotechnology News.
Built from transcriptomic and mass spectrometry data, the atlas uncovered more than 1,000 previously uncharacterized microproteins and pointed to a potential connection between one microprotein and microglial dysfunction in Alzheimer’s disease.
The post Microprotein Atlas Links Brain Immune Cell Dysfunction to Alzheimer’s appeared first on GEN - Genetic Engineering and Biotechnology News.
The study suggests that exosomes in the blood may promote the continued nerve irritation and dysfunction that underly why some people with shingles experience lingering pain long after the varicella zoster virus has cleared the body.
The post Exosomes Linked to Nerve Irritation, Dysfunction, and Lingering Pain After Shingles appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN webinar, our expert speaker, Emily Gaither, will present a systematic path from high-throughput resin screening to the selection and sequencing of two polishing steps, using emicizumab, an asymmetric IgG4 bsAb as a case study.
The post Right Resin, Right Order: A Two-Step Polishing Strategy for Bispecific Antibodies appeared first on GEN - Genetic Engineering and Biotechnology News.
The Sapio Scientific AI platform gives scientists a single, structured environment where experimental records connect directly to client deliverables and where time spent on data consolidation becomes time spent on science.
The post Consolidating Antibody Discovery Data with an AI Platform appeared first on GEN - Genetic Engineering and Biotechnology News.
Compared with the conventional synthesis of chemicals, fermentation-based processes can offer a more sustainable route to selected intermediates by reducing the need for organic solvents and minimizing process-related waste.
The post Evonik Expands in Slovakia appeared first on GEN - Genetic Engineering and Biotechnology News.
Pneumococcal bacterial subtypes influence how air pollution affects invasive disease risk, with certain strains linked to greater or faster risks of pneumonia, sepsis, and meningitis.
The post Pneumococcal Subtypes Influence the Impact of Air Pollution on Disease Risk appeared first on GEN - Genetic Engineering and Biotechnology News.
Study results suggest how a particular genetic variant can speed onset of Huntington disease motor symptoms by up to 12.5 years and accelerate clinical measures of disease progression, by driving runaway DNA changes inside the brain's most vulnerable neurons.
The post Why Does a Particular Genetic Variant Lead to Accelerated Huntington Disease Development? appeared first on GEN - Genetic Engineering and Biotechnology News.
Del-desiran was one of three clinical setbacks for Novartis within a week. On September 4, the company and partner Ionis Pharmaceuticals (Nasdaq: IONS) acknowledged that their co-developed pelacarsen failed the Phase III Lp(a)HORIZON trial (NCT04023552) by missing its primary endpoint of reducing the risk, compared with placebo, of cardiovascular events. Two days earlier, Novartis paused eight trials assessing its autoimmune and neurological disease candidate rapcabtagene autoleucel (rap-cel), after three patients treated with the personalized, CD19-directed chimeric antigen receptor T cell (CAR T) therapy died after experiencing immune effector cell-associated hemophagocytic syndrome.
The post StockWatch: Novartis Loses More than Market Value After Phase III Failure appeared first on GEN - Genetic Engineering and Biotechnology News.
By reproducing elements of human bone marrow on a chip, scientists have created a new tool that will help them gain new insights into how immune cells develop and function.
The post Bone Marrow-on-a-Chip Model Offers New Window Into Immune Cell Development and Behavior appeared first on GEN - Genetic Engineering and Biotechnology News.
Johns Hopkins researchers developed CloudScope, a cloud-based microscope enabling continuous, remote brain imaging in freely moving mice, revealing disease progression, seizures, cellular changes and behavior over extended periods.
The post CloudScope Enables Continuous Remote Monitoring of Brain Activity in Freely Moving Mice appeared first on GEN - Genetic Engineering and Biotechnology News.
Transcenta, headquartered in China and with a pipeline of over ten therapeutic antibody candidates, is a clinical-stage biopharmaceutical company with expertise in biologics discovery, translational research, clinical, and process development.
The post Transcenta Therapeutics and WuXi Biologics Team Up to Accelerate Commercialization of HiCB Technology appeared first on GEN - Genetic Engineering and Biotechnology News.
Alongside decisions involving capacity expansion, officials at Samsung Biologics announced that the company is pursuing opportunities to broaden its portfolio and address an increasingly diverse range of therapeutic modalities.
The post Samsung Biologics Signs $262 Million Manufacturing Agreement with European Pharma Firm appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers used DNA sequencing to map mutations in normal tissue from cancer patients undergoing different types of treatment. They found significant differences in the genetic mutations in healthy tissue, depending on whether the patients received radiotherapy, chemotherapy, or chemoradiation.
The post Cancer Treatment Genetic Effects in Healthy Cells May Reveal Clues to Side Effects and Resistance appeared first on GEN - Genetic Engineering and Biotechnology News.
Blocking PD-L2 reduced senescent cell accumulation in aged mice and improved measures tied to metabolic function and physical strength.
The post PD-L2 Blockade May Reduce Harmful Aging Cell Buildup appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN webinar, two experts will discuss the growing role of ddPCR in clinical research and translational oncology.
The post Highly Multiplexed Droplet Digital PCR for Ultra-Sensitive NSCLC Biomarker Detection in Research Workflows appeared first on GEN - Genetic Engineering and Biotechnology News.
Twenty-five years after 9/11, long-term monitoring of responders and survivors continues to reveal the complex health consequences of exposure to environmental toxins and hazardous materials.
The post What 25 Years of Research Have Revealed About 9/11’s Long-Term Health Effects appeared first on GEN - Genetic Engineering and Biotechnology News.
A preclinical study uncovered a novel pathway that links chronic IFN-II exposure to mitochondrial dysfunction and ultimately immunosuppression in cancer, creating foundational insights that may point to future therapies that combat immunotherapy resistance.
The post Chronic Interferon Exposure Linked to Immunosuppression in Cancer appeared first on GEN - Genetic Engineering and Biotechnology News.
A new study showed that a prgrammed lysis approach cut mechanical separation energy by over 50 percent at pilot scale, widening the range of bioalternatives that can compete pricewise.
The post Manus and UT Austin Advance Biomanufacturing Product Recovery Through BioMADE Program appeared first on GEN - Genetic Engineering and Biotechnology News.
In this sponsored podcast, LabVantage’s Gary Stimson digs into what it takes to build a data foundation for trustworthy AI.
The post Data Integrity as the Foundation for AI appeared first on GEN - Genetic Engineering and Biotechnology News.
Advances in media optimization, cell engineering, and AI are reshaping intensified bioprocessing for higher productivity, better quality, and greater manufacturing efficiency.
The post Smarter Cell Culture Starts with Better Media appeared first on GEN - Genetic Engineering and Biotechnology News.
Shinshu University Hospital's expertise in CAR T-cell therapy R&D and clinical application will be combined with Teijin Regenet's manufacturing and quality-management expertise cultivated through its CDMO business for regenerative medicine products.
The post CAR T Manufacturing in Japan Gets Boost from Teijin-Shinshu University Research Collaboration appeared first on GEN - Genetic Engineering and Biotechnology News.
As wet-lab validation becomes increasingly important to support artificial intelligence-enhanced science, research science points out that human-relevant cell models provide an important foundation for testing and confirming AI-generated insights.
The post Revvity Signs Agreement to Acquire Human Cell Design appeared first on GEN - Genetic Engineering and Biotechnology News.
A majority of biopharmas are expected to increase their reliance on CDMOs in coming years despite rising costs for their services.
The post Top 10 Contract Development and Manufacturing Organizations 2026 appeared first on GEN - Genetic Engineering and Biotechnology News.
As one notable company exits the field, growing CDMOs open facilities and secure major contracts. The companies are listed here for making headlines with facility openings, major contracts, and other significant actions, though not yet large enough to crack the A-List Top 10 CDMOs.
The post 10 CDMO Up & Comers 2026 appeared first on GEN - Genetic Engineering and Biotechnology News.
Del-desiran failed the Phase III HARBOR trial (NCT06411288) by missing the study’s primary endpoint of statistically significant improvement vs. placebo in video Hand Opening Time (vHOT) through week 54. vHOT is a frequently used measure of hand myotonia, according to a 2024 study, and involves clinical experts reviewing videos to measure the time from hand grip to opening.
The post Novartis Shares Slide After Neuromuscular Candidate Acquired with Avidity Fails Phase III Trial appeared first on GEN - Genetic Engineering and Biotechnology News.
Mutant NRAS has remained difficult to target in cancer. New findings suggest that its signaling partnership with wild-type HRAS may offer a targetable vulnerability, but effective strategies may need to be tailored to the specific NRAS mutation.
The post NRAS Mutations May Require Mutation-Guided Combination Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
A more coherent approach: a peptide-mapping LC-HRMS (liquid chromatography-high resolution mass spectrometry) workflow that can identify and monitor multiple product quality attributes, including selected critical quality attributes, and resolve modifications to specific sites. In a single analysis, deamidation, oxidation, site-specific glycoforms, sequence variants, and other product-related features monitored, potentially streamlining quality control across the product lifecycle.
The post The Multi-Attribute Method (MAM) as a Biologics Lifecycle Backbone appeared first on GEN - Genetic Engineering and Biotechnology News.
The HiBiT Target Cell Killing (TCK) platform, with off-the-shelf, mix-and-match components, measures four killing mechanisms for broad immunotherapy modality assessment.
The post ADCs, mAbs, CAR Ts: One Bioluminescent Platform Measures Them All appeared first on GEN - Genetic Engineering and Biotechnology News.
Sponsored content brought to you by Artificial intelligence is dramatically accelerating early drug discovery. Models can screen chemical space, predict structures, optimize properties, and propose new molecules at speeds that were unimaginable […]
The post AI Drug Discovery Hits a New Bottleneck: Experimental Validation appeared first on GEN - Genetic Engineering and Biotechnology News.
Rather than requiring genetic modification of the viral glycoprotein, G-Link uses a modular protein adaptor to blind native VSV-G tropism and redirect delivery after vector production.
The post Targeted Lentiviral Delivery Without Vector Reengineering appeared first on GEN - Genetic Engineering and Biotechnology News.
ProBioGen’s AGE1.CR.pIX is a stable proliferating avian cell line derived from duck embryo primary cells. It was developed as an alternative to the use of chicken eggs for large-scale vaccine production.
The post ProBioGen Grants Transgene Additional License for AGE1.CR.pIX Cell Line appeared first on GEN - Genetic Engineering and Biotechnology News.
A preclinical study in post-menopausal bone loss mouse models found that CADD522, a small-molecule drug targeting RUNX2, protected against osteoporosis, prevented fat gain, and reversed some of the metabolic changes linked to menopause.
The post Anticancer Candidate Strengthens Bones and Prevents Weight Gain in Postmenopausal Mice appeared first on GEN - Genetic Engineering and Biotechnology News.
The field of regenerative medicine is gaining momentum. Mesenchymal stem cells (MSCs) remain central to this field, with expanding applications as direct therapies and as producers of MSC-derived extracellular vesicles (MSC-EVs). This article examines the biological and regulatory factors shaping their promise.
The post Regenerative Medicine in the Bronze Age: MSCs and MSC-EVs Leading the Way appeared first on GEN - Genetic Engineering and Biotechnology News.
The PROPEL program aims to control gene expression through RNA structure, building logic-gated RNA therapies that switch on only where and when intended, without altering the genome.
The post RNAV8 Bio Joins ARPA-H Team to Pioneer Programmable RNA Medicines appeared first on GEN - Genetic Engineering and Biotechnology News.
The collaboration brings together Synastra’s expertise in genomic engineering, AAV vector design, rare-disease gene therapy, and translational development with NewBiologix’s proprietary cell engineering and rAAV manufacturing technologies.
The post NewBiologix and Synastra Join Forces to Advance rAAV Manufacturing for Duchenne Gene Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.
Medicines Discovery Catapult provided its investment and expert support to help two biotech companies accelerate the development of new treatments for a range of autoimmune, inflammatory, and age-related diseases.
The post Medicines Discovery Catapult Backs Two U.K. Biotech Companies Tackling Chronic Diseases appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers used a novel human 3D micro-bladder model to demonstrate how phage therapy could help to reduce recurrent urinary tract infections (UTIs) by attacking the reservoirs of bacteria hidden deep within the bladder wall, which antibiotics can’t address.
The post Micro-Bladder Model Demonstrates How Phage Therapy Could Help to Reduce Recurrent UTIs appeared first on GEN - Genetic Engineering and Biotechnology News.
