PPMI creates a large-scale proteomics resource designed to help researchers study Parkinson’s disease at the protein level and investigate biological signals associated with disease progression, patient heterogeneity, and potential biomarker development.
The post Thermo and Michael J. Fox Foundation Collaborate to Advance Proteomics-Enabled Parkinson’s Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.
Pangenome-guided breeding helped researchers combine high-altitude adaptation and improved yield in Tartary buckwheat by recovering useful wild alleles.
The post Pangenome-Guided Breeding Boosts Yield and High-Altitude Adaptation in Buckwheat appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN webinar, our expert speaker, Sam Zhang, PhD, will discuss emerging trends and capacity needs across the global late-stage microbial pipeline and CDMO landscape.
The post Advancing Microbial-Derived Biologics from Scale-Up to Commercial Production appeared first on GEN - Genetic Engineering and Biotechnology News.
Net present value modeling based on actual use and benchmark data was applied to quantify the net financial impact of an agentic AI solution to support a drug development program.
The post Financial Value of AI Agents in Drug Development appeared first on GEN - Genetic Engineering and Biotechnology News.
A study involving artificial hibernation in mice has shown how memories survive even after the brain temporarily loses more than half of its synaptic connections, challenging the long-held view that long-term memories depend on stable individual synapses.
The post Long-Term Memory Loss Secrets Revealed with Artificial Hibernation appeared first on GEN - Genetic Engineering and Biotechnology News.
Antibody reagent variability is a leading but frequently underappreciated source of irreproducible preclinical data. For in vivo studies, the problem is multidimensional: supply must simultaneously meet specifications for yield, purity, endotoxin control, […]
The post Producing Recombinant Antibodies for In Vivo Research appeared first on GEN - Genetic Engineering and Biotechnology News.
The next era of medicine will not be defined by earlier detection alone, but by understanding dynamics.
The post The Coming Shift from Biomarkers to Biological Trajectories appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN webinar, our expert speaker, Tao (Tony) Li, PhD, will discuss nanoparticle delivery opportunities beyond oncology and infectious disease, compare emerging nanocarrier platforms, and examine important CMC considerations critical for progressing from research through IND.
The post <i>In Vivo</i> Protein Generation Using Nanoparticle Delivery: Emerging Platforms and CMC Strategies appeared first on GEN - Genetic Engineering and Biotechnology News.
Omega polyunsaturated fatty acids are recognized for their myriads of health benefits, but a preclinical study has found that some omega fatty acids can restrain the cancer-killing capabilities of natural killer cells by acting through a receptor, LRP5.
The post Cancer-Fighting Abilities of NK Immune Cells May Be Disrupted by Some Omega Fatty Acids appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers reveal that radial glial progenitor lineage progression in cortical organoids differs from the developing mouse brain, highlighting the importance of stem-cell niche signals for faithful cortical development.
The post Cortical Organoids Reveal Radial Glial Progenitor Lineage Dynamics appeared first on GEN - Genetic Engineering and Biotechnology News.
Vivodyne confirms that it grows over 20 types of different human organ tissues, both healthy and with patient-linked diseases, including liver, lungs, gut, bone marrow, pancreas, kidney, eyes, and lymph nodes.
The post Human Biological Datacenter to Launch to Train World Model of Human Biology appeared first on GEN - Genetic Engineering and Biotechnology News.
American biotechnology hubs like Boston, Seattle, and San Diego are starting to wake up again. But will they be able to learn from the lessons of the recent past?
The post Biopharma’s Drawdown Is a Chance to Build Biotech Back Better appeared first on GEN - Genetic Engineering and Biotechnology News.
Cell and gene therapy developers should use software to help trace materials and data through the complex multi-stakeholder supply chains, manufacturing and distribution processes on which such products rely according to an industry expert.
The post Software Can Solve CGT’s Sectors Traceability Challenges appeared first on GEN - Genetic Engineering and Biotechnology News.
Bioprocessing companies face pressure to cut emissions while maintaining production standards. CRB experts said better data collection, strategic planning, and emerging technologies are helping facilities reduce energy use, improve efficiency, and build more sustainable operations.
The post Bioprocessing’s Green Shift Gains Momentum appeared first on GEN - Genetic Engineering and Biotechnology News.
An allogeneic CAR T-cell therapy company is planning a pivotal Phase III randomized-control trial, hoping their products can reach more patients and help those who can’t access autologous therapies.
The post Allogeneic CAR T Company Prepares to Widen Access to Patients appeared first on GEN - Genetic Engineering and Biotechnology News.
Self-optimization is the next evolutionary step for bioprocessing purification systems and, although that step is near, it currently is hindered by missing integrations among its many parts and by loose usage of precise concepts.
The post Five Steps to Enable Self-Optimizing Process Purification appeared first on GEN - Genetic Engineering and Biotechnology News.
For the first time, GEN's Alex Philippidis examines the top regions and top states just below the 10 largest regions for life sciences activity, as the field looks beyond the East and West Coasts for growth
The post Next 10 U.S. Biopharma Clusters appeared first on GEN - Genetic Engineering and Biotechnology News.
Dexamethasone reduced inflammatory signaling in human macrophages infected with Mycobacterium avium without increasing bacterial growth, suggesting a potential host-directed approach for nontuberculous mycobacterial disease.
The post Steroid Curbs Chronic Lung Inflammation Without Weakening Immune Defenses appeared first on GEN - Genetic Engineering and Biotechnology News.
Scientists identified a previously unknown way that the parasite Toxoplasma can adapt to growing in crowded environments of tissue cysts, and identified the protein TgPRO, as a dedicated regulator of metabolic gene expression in parasites.
The post Parasite-Specific Protein Helps <i>Toxoplasma</i> Adapt to Crowded Conditions appeared first on GEN - Genetic Engineering and Biotechnology News.
The world of biotech is showing strong signs of growth and clinical impact while also experiencing new challenges. The explosion of AI is reshaping areas from drug discovery and protein folding to gene editing and clinical trials. In GEN’s flagship virtual event we hear from a distinguished group of business executives, award-winning scientists, and journalists.
The post The State of Biotech 2026 appeared first on GEN - Genetic Engineering and Biotechnology News.
Different types of organoids grown from pluripotent, adult human stem cells can be combined into "assembloids" to better model complex organs that natively originate from combinations of different tissues.
The post Human iPSC-Derived Heart Assembloids Reproduce Valve Development and Disease appeared first on GEN - Genetic Engineering and Biotechnology News.
Bispecific antibodies are gaining momentum, and the demands on downstream purification will continue to grow. The case studies presented here illustrate how analytical insight forms the foundation of effective process development.
The post Bispecific Antibody Purification’s Complexity Problem and How to Fix It appeared first on GEN - Genetic Engineering and Biotechnology News.
Indiana has spent decades becoming a national leader in life sciences and pharmaceutical exports. Its strengths extend across universities, research institutes, manufacturers, suppliers, healthcare systems, and communities throughout the state.
The post Indiana Emerges as a Leading U.S. Biopharma Hub appeared first on GEN - Genetic Engineering and Biotechnology News.
Sponsored content brought to you by South Carolina just landed a $1.5 billion investment and more than 1,200 jobs, as Octapharma Plasma relocates its U.S. headquarters from Charlotte to Rock Hill and […]
The post How South Carolina Became the Southeast’s Fastest Growing Biotech Hub appeared first on GEN - Genetic Engineering and Biotechnology News.
Research into the biological processes underpinning aging is essential for improving prevention strategies and developing treatments that support healthier aging.
The post The Future of Aging Research Is Longitudinal, Multiomic, and Single-Cell appeared first on GEN - Genetic Engineering and Biotechnology News.
The steady run of investment since, from Lilly’s $5 billion plant to a 10,500-square-foot lab expansion in downtown Richmond, suggests the region intends to keep building on it.
The post Greater Richmond’s Pharma Cluster Keeps Compounding appeared first on GEN - Genetic Engineering and Biotechnology News.
Among key factors in the decision, according to BMS, were the emerging strength of Greater Houston’s life sciences workforce in life sciences, proximity to utilities and transportation infrastructure, an overall business climate conducive to long-term growth—and available incentives.
The post BMS Chooses Houston for $2.3B Manufacturing Facility appeared first on GEN - Genetic Engineering and Biotechnology News.
Drug-resistant Candida auris was found to persist in hair follicles by exposing chitin, triggering interferon-γ that suppresses skin defenses and creates a niche for fungal colonization.
The post <i>Candida auris</i> Persists in Hair Follicles, Hijacks Immune Signaling appeared first on GEN - Genetic Engineering and Biotechnology News.
Unlike prediction-based approaches, Broken String Biosciences says BaseMap ABE generates genome-wide data directly from biologically relevant cells, providing researchers with clear understanding of editor specificity under physiologically relevant conditions.
The post BaseMap ABE Launched for Off-Target Characterization in Base Editing Therapeutic Development appeared first on GEN - Genetic Engineering and Biotechnology News.
Scientists linked early-life stress experience in mice to long-term stress hypersensitivity within the brain’s dopaminergic circuitry, providing a mechanism by which early-life stress increases risk for mood and anxiety disorders later in life.
The post Early-Life Stress Leaves Epigenetic “Scars” That Prime Stress Sensitivity appeared first on GEN - Genetic Engineering and Biotechnology News.
Lilly now expects to rack up between $85 billion and $87 billion in revenue this year, up 2.4% to 3.7% from its previous range of between $82 billion and $85 billion. That change raised the midpoint of Lilly’s revenue forecast from $85.5 billion to $86 billion.
The post StockWatch: Lilly Rises on Revenue Leap; Analysts High on Krystal Despite Revenue Miss appeared first on GEN - Genetic Engineering and Biotechnology News.
A scalable platform to discover molecular glue degraders has been developed, identifying the first metabolically activated glue. The approach expands protein degradation targets, enabling selective elimination of previously undruggable cancer-related proteins for therapeutic development.
The post Novel Molecular Glue Discovery Platform Unlocks Undruggable Cancer Targets appeared first on GEN - Genetic Engineering and Biotechnology News.
A small Phase I trial found that fecal microbiome transplantation (FMT) increased peanut tolerance in some adults with a peanut allergy, while mouse studies suggested the effect may depend on bile acid metabolites.
The post FMT Shows Promise for Peanut Allergy Tolerance in Phase I Trial appeared first on GEN - Genetic Engineering and Biotechnology News.
Mingyu Qiao, PhD’s recent work focused on DHA, critical to fetal and infant brain and eye development. The DHA will be produced in a microalgal strain isolated in Qiao’s lab.
The post Algae-Based Food Product Development Earns Gates Foundation Award appeared first on GEN - Genetic Engineering and Biotechnology News.
Research scientists previously discovered that a gene connected to a protein called collagen IX, which helps hold the disc's structural fibers together, has been repeatedly linked to early-onset disc problems.
The post Genetic Findings Provide Insights Into Leading Cause of Back Pain appeared first on GEN - Genetic Engineering and Biotechnology News.
Transplanted human interneurons, a type of nerve cell, formed working connections in the injured spinal cords of rats and improved breathing, supporting their potential as a possible treatment for spinal cord injuries in people.
The post Engineered Human Interneuron Transplants Repair Respiratory Circuits in Injured Rats appeared first on GEN - Genetic Engineering and Biotechnology News.
In this edition of the Nautilus Biotechnology “Proteomics and neuroscience” eBook, we’re excited to dive into tau biology, share what researchers are learning about tau and its role in Alzheimer’s disease using the Nautilus Voyager Platform, and invite you to use the Nautilus Voyager Platform in your own work through the Iterative Mapping Early Access Program.
The post Tau and Alzheimer’s Disease appeared first on GEN - Genetic Engineering and Biotechnology News.
Advanced chromatography resins and data-driven strategies are redefining monoclonal-antibody purification in modern biopharmaceutical manufacturing.
The post Renewed Importance of CEX in Monoclonal-Antibody Purification appeared first on GEN - Genetic Engineering and Biotechnology News.
The results of a preclinical study demonstrated that phosphorylated tau enters mitochondria and initiates a vicious cycle of pathological events that trigger reverse electron transport.
The post Tau Protein Linked to Mitochondrial Reverse Electron Transport in Preclinical Models appeared first on GEN - Genetic Engineering and Biotechnology News.
DNA Script says the company is contributing its EDS technology and acting as a technical solution integrator for the project, while adapting its solution to incorporate GE HealthCare’s proprietary DNA scaling technology.
The post DNA Script Wins ARPA-H Award to Advance DNA Manufacturing appeared first on GEN - Genetic Engineering and Biotechnology News.
COVID-19 can reactivate dormant viruses, including Epstein-Barr and cytomegalovirus, according to a large NIH-funded study. Researchers also linked Anelloviridae reactivation to long COVID, revealing potential targets for future diagnostics and treatments.
The post COVID-19 Reactivates Dormant Viruses, Offering New Clues to Long COVID appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers working with mice identified an immune pathway that prevents what is normally a harmless fungus, Candida albicans, from developing into a fatal infection.
The post Immune Pathway Identified That Prevents <i>C. albicans</i> Infection from Becoming Deadly appeared first on GEN - Genetic Engineering and Biotechnology News.
Frank Fazio discusses the workforce needs of bioprocessing, the challenges of attracting and retaining talent, and how partnerships with schools, colleges, and universities are helping St. Jude build a sustainable talent pipeline for the future.
The post Building a Bioprocessing Workforce Through Partnerships appeared first on GEN - Genetic Engineering and Biotechnology News.
Selecting the best AI models for each step of a workflow while properly preparing structured and unstructured enterprise data enables a more effective systems engineering approach for biomanufacturing.
The post AI “Council of Models” Improves Workflows and Outcomes appeared first on GEN - Genetic Engineering and Biotechnology News.
An innovative rotating drum bioreactor designed to maximize the availability of dissolved oxygen throughout the entire fermentation cycle could significantly increase mAb production yields.
The post New Bioreactor Design Could Boost mAb Yields appeared first on GEN - Genetic Engineering and Biotechnology News.
NeX, which is built on the EnzeneX continuous manufacturing (FCCM) platform, is designed to deliver a turnkey and scalable way to make biologics manufacturing transportable, close to patients and supply chains.
The post Enzene Targets Local Biomanufacturing with New Solutions appeared first on GEN - Genetic Engineering and Biotechnology News.
The puppies represent a key first step towards addressing canine allergenicity and mark potentially a significant advance in veterinary biotechnology.
The post Fur Real: Biotech Startup Eliminates Major Dog Allergen in Beagle Pups Using CRISPR appeared first on GEN - Genetic Engineering and Biotechnology News.
The target’s significance, according to Recursion and its partners, rests in its potential to expand the universe of neuroscience treatments beyond the handful of familiar targets in the space. While more than three billion people are affected by neurological conditions worldwide, only one in 40 neuroscience drugs to ever reach the clinic have been approved.
The post Recursion Partners with Genentech to Advance First Validated Neuro Target Discovered Through AI Map appeared first on GEN - Genetic Engineering and Biotechnology News.
Building a highly technical, highly regulated pharmaceutical facility takes years, and we are in the part of the cycle where the work is physical, not scientific. Companies and their talent partners need to know exactly where they sit in that timeline and plan against it.
The post Onshoring Is Here. The Hiring Wave Is Still a Decade Out appeared first on GEN - Genetic Engineering and Biotechnology News.
An AI-based method uses MRI scans to generate detailed maps highlighting how different areas of the brain age, and shedding light on how patterns of brain changes correlate with changes in cognitive function across lifespan.
The post AI Uses MRIs to Generate Brain Aging Maps for Neurodegenerative Disease Research appeared first on GEN - Genetic Engineering and Biotechnology News.
In this GEN podcast, an expert from LabVantage explores how regulated laboratories can build this foundation, break down data silos, and prepare for AI adoption in clinical and commercial settings.
The post Beyond the Technology: AI Readiness in Regulated Laboratories appeared first on GEN - Genetic Engineering and Biotechnology News.
The CRAB Lab builds on a long-standing partnership between UMD and NIST through IBBR, which will serve as the physical home for instrumentation, facilities, and scientific expertise.
The post NSF-Funded Test Bed Lets Researchers Program Automated Biomanufacturing Workflows appeared first on GEN - Genetic Engineering and Biotechnology News.
ILC3s help regulate inflammation and maintain barrier integrity, but their rarity has made them difficult to study with conventional genome-organization methods.
The post Genome Mapping Reveals Autoimmune Disease Risk Genes in Innate Lymphoid Cells appeared first on GEN - Genetic Engineering and Biotechnology News.
The first use of combined phage therapy and fecal microbiota transplantation for recurrent urinary tract infections reduced antibiotic use and improved quality of life in three women, supporting future clinical trials.
The post Combined Phage Therapy and FMT Reduces Recurrent UTIs and Antibiotic Use in First Human Case Series appeared first on GEN - Genetic Engineering and Biotechnology News.
A new study has found that the signals cells use to switch genes on have remained almost unchanged across two billion years of evolution, but the ones used to switch genes off vary dramatically from one branch of life to another.
The post Evolutionarily Diverse Organisms Switch Genes on Simply and Switch Them off Dynamically appeared first on GEN - Genetic Engineering and Biotechnology News.
The collaboration is specifically focused on applying Receptor.AI's computational platform to Sethera's proprietary polymacrocyclic peptide chemistry, encoded screening data, and resulting therapeutic candidates. Each company will retain its background platform technologies.
The post Receptor.AI and Sethera Plan to Create Closed-Loop Discovery and Optimization Workflow for Difficult Therapeutic Targets appeared first on GEN - Genetic Engineering and Biotechnology News.
After seeing its lead candidate rejected by the FDA last year, Capricor Therapeutics is hoping for a better outcome for its resubmitted BLA for its lead pipeline candidate Deramiocel.
The post StockWatch: Capricor Plunges as FDA Panel, Staff Question Effectiveness of Lead Candidate Deramiocel appeared first on GEN - Genetic Engineering and Biotechnology News.
A study in mice has shown how shown that microglia immune cells in the brain play a critical role in how the brain recovers from ketamine anesthesia, and indicates that there are differences between female and male brains.
The post Ketamine Triggers Sex-Specific Brain Recovery Responses appeared first on GEN - Genetic Engineering and Biotechnology News.
Through a multistep process, signals from infected cells trigger the formation of a receptor complex that directs neutrophils out of blood vessels toward infection sites without damaging healthy tissue.
The post Molecular GPS Guides Neutrophils to Sites of Infection appeared first on GEN - Genetic Engineering and Biotechnology News.
The metabolite 10-hydroxystearic acid (10-HSA), from Lactiplantibacillus plantarum, repaired HIV-related gut damage, reduced inflammation, restored immunity, and improved antiretroviral therapy effectiveness in preclinical primate studies, supporting future human trials.
The post Microbiota-Derived Metabolite Enhances HIV Therapy in Monkeys appeared first on GEN - Genetic Engineering and Biotechnology News.
In this episode of GEN's Touching Base, editors discuss business news from Axiom and Latigo, and science updates on the potential roots of fibromyalgia and base editing for Huntington’s disease.
The post Axiom’s Hong Kong Bet, Latigo’s Positive Phase II, and Base Editors for Huntington’s appeared first on GEN - Genetic Engineering and Biotechnology News.
The team integrated high-resolution spatial transcriptomics, single-cell RNA sequencing, and chromatin-accessibility profiling across nine sequential stages of lung colonization in mouse models.
The post Spatiotemporal Multiomics Charts Cellular Dynamics of Liver Metastasis appeared first on GEN - Genetic Engineering and Biotechnology News.
Scientists developed a platform, GOOSE, allowing them to design disordered proteins at a large scale, offering a lens through which to investigate how their component sequences affect the cell and how changes in such proteins might drive diseases.
The post A Computational Framework for Designing Disordered Proteins at Large Scale appeared first on GEN - Genetic Engineering and Biotechnology News.
Crosstalk between mitochondrial metabolism and epigenetic regulation helps activate the inflammatory SASP in senescent cells, revealing a potential therapeutic target for limiting chronic inflammation during aging.
The post Mitochondrial–Epigenetic Pathway Linked to Age-Related Inflammation appeared first on GEN - Genetic Engineering and Biotechnology News.
LTG-001 achieved the primary endpoint of the Phase IIb LTG-001-010 trial (NCT07102459) by achieving better-than-placebo scores in the time-weighted sum of the pain-intensity difference (SPID) over the 48-hour treatment period (SPID48), based on the 0-10 range of scores of the Numeric Pain Rating Scale, with higher SPID48 values indicating greater pain reduction.
The post Latigo Reports Positive Phase IIb Data for Non-Opioid Acute Pain Candidate appeared first on GEN - Genetic Engineering and Biotechnology News.
Elix and the University of Vienna will partner to bridge the gap between advanced structural biology and artificial intelligence. By integrating AI’s predictive power with experimental atomic-resolution data, the project seeks to bypass the limitations of traditional drug discovery, delivering new therapeutic insights for complex diseases.
The post Elix and University of Vienna Aim to Advance Drug Discovery Using AI appeared first on GEN - Genetic Engineering and Biotechnology News.
A GWAS meta-analysis including 2.5 million individuals identified 26 genetic risk factors linked with fibromyalgia, identifying risk variants in 26 regions of the genome, many which are involved in brain and nerve function.
The post Genetic Study of Fibromyalgia Points to Neurological Basis appeared first on GEN - Genetic Engineering and Biotechnology News.
By precisely altering the huntingtin gene rather than switching it off, an in vivo CRISPR base-editing approach reduced toxic protein fragments and disease symptoms in mouse models of Huntington’s disease.
The post Base Editing Strategy Alleviates Huntington’s Disease in Mice appeared first on GEN - Genetic Engineering and Biotechnology News.
A Phase III trial found the donor-derived cell therapy deramiocel slowed arm muscle decline in boys and young men with advanced Duchenne muscular dystrophy, with potential benefits for heart health and a favorable safety profile.
The post Landmark Phase III Trial Finds Cell Therapy Slows Muscle Decline in Advanced DMD appeared first on GEN - Genetic Engineering and Biotechnology News.
The collaboration brings together Celonic’s expertise in cell line development, drug substance process development, intensified bioprocessing, and GMP manufacturing with Leukocare’s data science-driven approach to drug product development.
The post Celonic and Leukocare Collaborate to Support Complex Biologics and Advanced Drug Development appeared first on GEN - Genetic Engineering and Biotechnology News.
A new perfusion-bioreactor platform developed by researchers in France offers tighter control of large bioprinted tissue cultures, combining regulated growth conditions with MRI monitoring to improve reproducibility and support future advances in drug testing and regenerative medicine.
The post Large Bioprinted Tissues Get a Precision Boost appeared first on GEN - Genetic Engineering and Biotechnology News.
Modular flow-through and pseudo-affinity downstream processing technologies enable high flow-through and high impurity capture to help biomanufacturers minimize backlogs caused by the combination of complex vectors and process intensification.
The post Downstream Purification Platform Breaks Complex Vector Bottleneck appeared first on GEN - Genetic Engineering and Biotechnology News.
NIBRT predicts that the market for GLP-1 receptor agonist-based diabetes and obesity meds will increase demand for biopharmaceutical engineers with a mix of synthetic chemistry and biotech skills.
The post Biopharma Hungry for GLP-1 Receptor Agonist Manufacturing Skills appeared first on GEN - Genetic Engineering and Biotechnology News.
Manufacturing costs for therapies based on adeno-associated viruses (AAV) could fall thanks to careful work on plasmid redesign and cell-line selection by a company with long-term expertise in capsid discovery.
The post Capsid Experts Hope to Slash the Cost of Gene Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
The researchers identified Nys34 as a leading candidate after it demonstrated three-to-eightfold lower toxicity than amphotericin B in multiple human cell lines and reduced fungal burden in a mouse model of invasive aspergillosis.
The post Genome Mining Points to Less Toxic, More Potent Polyene Antifungals in Mice appeared first on GEN - Genetic Engineering and Biotechnology News.
In a new publishing deal, Causaly and Sage have announced a partnership to bring full-text scientific peer-reviewed literature into the world of AI-powered drug discovery research. The deal also marks Causaly’s first partnership with a major STM publisher.
The post Sage Inks Licensing Deal with Causaly’s AI Platform Focusing on Drug Discovery Research appeared first on GEN - Genetic Engineering and Biotechnology News.
By mapping the organization of fascicles and fibers, investigators expect to gain critical insights into how the vagus nerve communicates with various organs and influences human health and disease.
The post Comprehensive Human Vagus Nerve Map Unveiled appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers developed a soft, wearable fingertip patch that continuously tracks a Parkinson's disease patient’s levodopa medication levels by measuring chemicals in their sweat, with no batteries required.
The post Parkinson’s Disease Medication Monitored with Fingertip Sweat Patch appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers solved the mystery of why stimulating and blocking a receptor in the brain can help people lose weight, and suggested that the results of their mouse studies could aid the design of drugs that stimulate more weight loss with fewer side effects.
The post Solving the Mystery of Why Blocking and Stimulating a Brain Receptor Helps Weight Loss appeared first on GEN - Genetic Engineering and Biotechnology News.
Proteomics study identifies a 19-protein blood signature that predicts ALS symptom onset up to five years before clinical diagnosis, offering a potential tool to guide earlier intervention and preventive treatment before irreversible nerve damage occurs.
The post ALS Could Be Predicted Years Before Symptoms, Proteomics Study Finds appeared first on GEN - Genetic Engineering and Biotechnology News.
Axiom says the special administrative region of China possesses deep biotechnology expertise, a strong appetite for clinical-stage innovation, and direct proximity to the Asian partners and capital advancing the company’s science.
The post StockWatch: Axiom CEO Explains Plans for Hong Kong IPO appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers generated off-the-shelf, mass-producible iPSC-derived allogeneic γδT cells that in a small preclinical study suppressed tumor growth in mouse colorectal cancer xenograft models, highlighting the cells’ potential as a novel immunotherapy for colorectal cancer.
The post Colorectal Cancer Targeted with Mass-Produced iPSC-Derived Allogeneic T Cells appeared first on GEN - Genetic Engineering and Biotechnology News.
An oral antiviral candidate prevented airborne and contact transmission of a measles-like virus in ferrets, reduced disease severity and infectious duration, and could complement vaccination strategies to help control future measles outbreaks.
The post Oral Antiviral Blocks Measles-Like Virus Transmission in Ferrets appeared first on GEN - Genetic Engineering and Biotechnology News.
Atlases like this one can provide the labeled, cell-type-resolved training data that artificial intelligence models need to make accurate predictions—a bottleneck that has historically limited the field.
The post Single-Cell Atlas Simultaneously Maps 3D Genome Architecture and DNA Methylation appeared first on GEN - Genetic Engineering and Biotechnology News.
Using single-cell multiomics, spatial transcriptomics, and an AI model called Hicformer, the team generated a multiscale view connecting genome structure, gene regulation, and tissue organization in Alzheimer’s disease.
The post Single-Cell Maps Reveal Genome Reorganization in Alzheimer’s Brain Cells appeared first on GEN - Genetic Engineering and Biotechnology News.
The results of a mouse study suggest that inflammation during pregnancy can trigger autism-like brain and behavior changes in offspring, and that the effects may be rapidly but temporarily reversible in adulthood with a dose of the immunosuppressive drug rapamycin.
The post Autism-Like Traits in Mice Improved After Single Rapamycin Dose appeared first on GEN - Genetic Engineering and Biotechnology News.
Solar energy generates electricity to produce hydrogen, which combines with carbon dioxide to make methanol. Specialized enzymes then convert methanol into specific amino acids, depending on the enzyme combination used.
The post Turning Solar Power Into Protein appeared first on GEN - Genetic Engineering and Biotechnology News.
An analysis of aging human brains revealed widespread immune remodeling, blood-brain barrier deterioration, and genome architecture changes, challenging long-held assumptions about how the brain's resident immune cells are maintained.
The post Midlife Brain Aging Linked to Immune Cell Remodeling, Blood-Brain Barrier Decline appeared first on GEN - Genetic Engineering and Biotechnology News.
Samsung views the deal as expanding its capabilities beyond antibodies and ADCs to include peptide therapeutics, while advancing innovation across high-growth areas such as oncology and other emerging indications.
The post Samsung Proposes Offer to Acquire Swiss CDMO Specializing in Peptides appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers identified a form of transmissible cancer in a freshwater fish species, in which the cancer cells behave more like parasites than conventional tumors, moving from fish to fish.
The post Transmissible Cancer Discovered in Freshwater Fish appeared first on GEN - Genetic Engineering and Biotechnology News.
The Palo Alto-based company is developing small molecule drugs that modulate the transcriptome. The latest funding raise will advance IND-enabling studies and clinical preparation of its neurological disease portfolio.
The post Transcripta Bio Raises $24M for AI-Driven Neurological Disease Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
Generating biomanufacturing-relevant data on protein production in a large-scale, AI-enabled database is still rare. When commercialized, it may substantially improve development timelines and optimization success rates.
The post AI Protein Engineering Model Designed for Biomanufacturing appeared first on GEN - Genetic Engineering and Biotechnology News.
Manufacturers are developing innovative techniques to test for particulates in cell-containing products amid unclear regulatory guidance. Process simulation, minimizing particulates during production, and choosing the right tests can help.
The post Cell-Therapy Manufacturers Get Creative on Checking Particulates appeared first on GEN - Genetic Engineering and Biotechnology News.
Cell and gene therapy leaders discuss the industry’s biggest bioprocessing challenges, from manufacturing scalability and raw-material variability to infrastructure readiness, and explain the strategies they believe will accelerate commercialization and improve patient access.
The post Scaling Cell and Gene Therapy Manufacturing appeared first on GEN - Genetic Engineering and Biotechnology News.
Single-use technologies (SUTs) are less environmentally friendly than previously thought, according to new research. In some cases stainless steel technologies (SSTs) are the more sustainable option. Better still may be a combination.
The post Hybrid Single-Use and Stainless-Steel Plants the Greener Option appeared first on GEN - Genetic Engineering and Biotechnology News.
Lonza, through one of its affiliated companies, is eligible to receive upfront, clinical, regulatory, and commercial milestone payments, plus royalties on the net sales of resulting products.
The post Engitix Licenses Lonza’s Technology to Advance ADC Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
UC San Diego has joined the Innovative Genomics Institute as its fourth UC partner, expanding collaboration to develop next-generation genome-editing technologies that address major health, climate, agriculture, and environmental challenges through interdisciplinary research.
The post UCSD, IGI Partnership Expands CRISPR Innovation Across Health, Agriculture, and the Environment appeared first on GEN - Genetic Engineering and Biotechnology News.
Traditionally focused on research tools for academic, government, and industry customers, 10x has moved this year to launch clinical collaborations with top-tier institutions—the most recent of which was announced last month with Cleveland Clinic. The nonprofit multispecialty academic medical center is partnering with 10x in a multi-year collaboration aimed at advancing research in novel diagnostics for bladder cancer.
The post 10x Clinical Expansion Advances with CLIA Lab Plans, Cleveland Clinic Partnership appeared first on GEN - Genetic Engineering and Biotechnology News.
An AI-based approach assesses disease severity in patients with myelodysplastic neoplasms (MDS), a form of blood cancer where one-third of patients progress to a more aggressive state called acute myeloid leukemia.
The post Blood Cancer Therapies Informed by Spatial Remodeling of Bone Marrow appeared first on GEN - Genetic Engineering and Biotechnology News.
Built for early-stage biotechs, the program combines access to Signals software with guided onboarding and best-practice configurations for smaller biotechs to help accelerate innovation, improve scientific productivity, and shorten time-to-value.
The post Revvity Creates Program to Equip Young Biotechs with Scalable Informatics Capabilities Sooner than Later appeared first on GEN - Genetic Engineering and Biotechnology News.
