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Researchers developed an injectable hemostatic microgel to help reduce bleeding in infants undergoing surgery, which in animal testing reduced blood loss by 50-60% and enhanced fibrin deposition at wound sites. The post Injectable Microgel Developed to Reduce Bleeding in Infants Undergoing Surgery appeared first on GEN - Genetic Engineering and Biotechnology News.
By combining CRISPR screening with epigenetic targeting, scientists identified a group of enzymes that could be inhibited to restore tumor suppressor activity and reduce leukemia burden in AML mouse models. The post Epigenetic Strategy Restores Tumor Suppressor in Acute Myeloid Leukemia Models appeared first on GEN - Genetic Engineering and Biotechnology News.
The team engineered vertical micropillars—each tens of times thinner than a human hair—using a microfabrication process called photolithography that allowed them to precisely tune diameter, spacing, and stiffness. The post Hydrogel-Based Axon Model Improves Early Testing for MS Remyelination Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.
GATC Health says that an AI-driven in silico multi-omics approach shaves time off preclinical development by derisking programs early-on and expanding opportunities. The post AI <i>In Silico</i> Multi-Omics Technique Cuts Therapeutic Development Costs appeared first on GEN - Genetic Engineering and Biotechnology News.
The past year marked a proverbial inflection point for organoid models designed to uncover biological insights previously unattainable through traditional cell culture experiments or animal models. The post Top 10 Organoid Companies appeared first on GEN - Genetic Engineering and Biotechnology News.
For the genomics community February means the season of big announcements as the AGBT meeting—which has earned a reputation for breaking field-shaping news—takes place. The meeting is packed not only with technology announcements in the sponsor suites, but also with scientific talks in the sessions to showcase how the technology is being used to address new biological questions. This year's meeting did not disappoint. The post AGBT 2026 Recap: NGS Big Bets and Spatial’s Rising Momentum appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers developed a method to assemble n-doped poly(benzodifurandione) (n-PBDF) in vivo from injected monomers, using an organism’s native catalysts, specifically, abundant hemoproteins, to build conductive polymers directly in the brain. The post Growing Conductive Polymers Directly in the Brain appeared first on GEN - Genetic Engineering and Biotechnology News.
Researchers developed novel, first-in-class drugs that inhibit both HIF-1 and HIF-2 and which, combined with immunotherapy, eliminated breast, colorectal, melanoma, and prostate tumors in mice, suggesting that the drugs could eventually be used to treat a broad range of cancers in humans. The post Combining Novel Dual HIF Inhibitors with Immunotherapy Erases Multiple Tumor Types in Mice appeared first on GEN - Genetic Engineering and Biotechnology News.
In this Point of View column, Mike Garrett, CEO of Taconic Biosciences, explores redefining preclinical models for the future of drug development. The question is no longer whether animal models still have a place in modern drug development, but how they can be used more judiciously and responsibly. When integration guides decision-making, the result is a more efficient therapeutic pipeline, greater regulatory confidence, and meaningful progress toward the goals of the 3Rs. A win for science; a win for patients; and, ultimately, a win for animals. The post Integration Over Elimination appeared first on GEN - Genetic Engineering and Biotechnology News.
Today’s organoid companies underscore proof points in the ability to model complex human biology with high fidelity. At the same time, the government’s evolving regulatory stance is serving as a critical catalyst, providing both validation and momentum to accelerate widespread adoption of these platforms. The post Accelerating Organoid Adoption Set to Transform Cancer Drugs appeared first on GEN - Genetic Engineering and Biotechnology News.
Antibody-drug conjugates (ADCs) have evolved from an elegant scientific concept into one of oncology’s most dynamic therapeutic classes. By fusing the targeting specificity of monoclonal antibodies with the cell-killing power of highly […] The post Targeted Precision, Complex Promise appeared first on GEN - Genetic Engineering and Biotechnology News.
In this Thought Leader article, Campbell Bunce, PhD, CSO of Abzena writes about advances in platform design, genome engineering, and integrated workflows are prompting the industry to reassess long-held assumptions and move away from purely sequential approaches to CLD. The post Cell Line Development Has to Evolve appeared first on GEN - Genetic Engineering and Biotechnology News.
Antibody-drug conjugates (ADCs) constitute a rapidly evolving class of targeted oncology therapeutics that couple tumor-selective antibodies with highly potent cytotoxins. At the 16th Annual World ADC Conference, leaders across discovery, development, and manufacturing highlighted the accelerating momentum of this clinically maturing field. The post Precision Engineering Defines Next-Gen ADC appeared first on GEN - Genetic Engineering and Biotechnology News.
A whole exome sequencing study in women carrying a pathogenic BRCA1 mutation found that damaging variants in genes involved in innate immunity, and particularly NK cell activation, are significantly linked to earlier breast cancer onset. The post Immune Response Gene Variants Tied to Earlier Breast Cancer in <i>BRCA1</i> Carriers appeared first on GEN - Genetic Engineering and Biotechnology News.
PRISM ALS aims to develop, evaluate, and make available a diverse panel of well-characterized, patient-derived induced pluripotent stem cell (iPSC) models that capture both genetic and sporadic forms of ALS. The post Biological Complexity of ALS to Be Addressed by the Development of New Stem Cell Models appeared first on GEN - Genetic Engineering and Biotechnology News.
Many new personalized cancer vaccines (PVCs) platforms are at or near the clinical stage and showing great promise. Design concepts include viral, bacterial, and synthetic vectors as well as the direct use of tumor cells to sensitize the immune system. Each system comes with its own set of trade-offs in terms of manufacturing process, safety, and ease of use for patients. The post Cancer Vaccine Design Gets Personal appeared first on GEN - Genetic Engineering and Biotechnology News.
Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers critical insight into how cancer and […] The post Spatial Biology appeared first on GEN - Genetic Engineering and Biotechnology News.
An automated “text mining” and knowledge graph-based analytical approach can help biopharmaceutical process developers better understand how cell culture conditions influence glycosylation during therapeutic protein manufacturing. The post Text Mining Culture Conditions and Glycosylation Relationships appeared first on GEN - Genetic Engineering and Biotechnology News.
Crude-oil price spikes following military strikes on Iran expose bioprocessing’s dependence on fossil inputs, highlighting sustainability challenges and rising biologics costs as industry efforts toward defossilization struggle against volatile energy markets and supply realities. The post Defossilization Needs to Be Critical Target in a Sustainability Program appeared first on GEN - Genetic Engineering and Biotechnology News.
Peptonics, a new class of peptide-based surfactants, improves upon the commonly used poloxamer family, with virtually no foaming and higher productivity in CHO and HEK293 cell cultures used to produce mAbs and AAVs. The post Peptonics Solves Cell Culture Defoaming Debacle appeared first on GEN - Genetic Engineering and Biotechnology News.
Solid tumors are heterogeneous with an immunosuppressive tumor microenvironment, but that is not slowing the search to treat the most difficult, recalcitrant cases. The post Engineering Biology to Fight Cancer appeared first on GEN - Genetic Engineering and Biotechnology News.
As gene therapies advance toward indications with larger patient populations, adeno-associated virus (AAV) manufacturers are under growing pressure to deliver high-quality vectors at substantially larger scales. In this April issue tutorial John Schiel, PhD, discusses enabling consistent, high-titer AAV production. The post Prolonged Transfection Complex Stability for Reliable Large-Scale AAV Manufacturing appeared first on GEN - Genetic Engineering and Biotechnology News.
From designing drugs with a text prompt to XR-guided experiments, agentic AI is transforming the modern lab. NVIDIA GTC brought together life science leaders to discuss how these advances are transforming biology. The post Can AI Agents Automate Scientific Discovery? appeared first on GEN - Genetic Engineering and Biotechnology News.
Initially, UMass Chan researchers will work with Trenchant BioSystems to evaluate blood products to separate stem cells and build the automated gene transfer genetic engineering platform with Caring Cross lentiviral vectors. The post Advancing the Manufacture of Patient Accessible Cell and Gene Therapies at Place-of-Care appeared first on GEN - Genetic Engineering and Biotechnology News.
People with celiac disease have impaired small intestinal fiber metabolism due to missing key gut bacteria, suggesting microbiome-targeted therapies alongside diet may improve healing and treatment outcomes. The post Celiac Disease Study Reveals Fiber Benefits Depend on Gut Microbiome appeared first on GEN - Genetic Engineering and Biotechnology News.
Engineered cells that target uPAR selectively eliminated both solid tumor cells and fibroblasts and immunosuppressive myeloid cells that provide a protective environment for tumor growth. The post CAR T-Cell Therapy Unlocks Solid Tumors, Targets uPAR Surface Protein in Mice appeared first on GEN - Genetic Engineering and Biotechnology News.
Protein evolution remains tightly constrained by ancestral starting points. By comparing real protein families with simulated evolution, researchers reveal why natural diversity occupies only a narrow region of sequence space. The post Common Ancestry Limits Protein Sequence Exploration, Computational Study Shows appeared first on GEN - Genetic Engineering and Biotechnology News.
A large autism genomics study in Latin American populations identifies shared risk genes across ancestries, supporting universal genetic architecture, improving diagnostic equity, and highlighting the importance of diverse representation in genetic research. The post Autism Risk Genes Largely Shared Across Global Populations appeared first on GEN - Genetic Engineering and Biotechnology News.
An in vitro study showed how impaired transport protein and buildup of ceramides at the endoplasmic reticulum can help lock cells into replicative senescence, potentially pointing to avenues for research on cell aging. The post Link Between Ceramide Transport and Cell Senescence Could Inform Aging Biology Research appeared first on GEN - Genetic Engineering and Biotechnology News.
The goal is to make good data practices the path of least resistance. Perhaps the most important requirement is software that experimental scientists can use naturally within their existing workflows. The post Why Data Infrastructure Determines AI Success in Drug Discovery appeared first on GEN - Genetic Engineering and Biotechnology News.
Lilly has agreed to pay Insilico $115 million upfront, as well as development, regulatory, and commercial milestones. Insilico will grant the pharma giant an exclusive global license to develop, manufacture, and commercialize “potentially best-in-class, novel oral therapeutics." The post Lilly Grows AI Footprint with Up-to-$2.75B Insilico Collaboration appeared first on GEN - Genetic Engineering and Biotechnology News.
African trypanosomes evade immunity by switching surface proteins and using ESB2, an RNA “shredder,” to control gene expression via RNA decay, revealing new vulnerabilities and potential treatments for sleeping sickness. The post African Trypanosomes Use a Molecular Shredder to Avoid Detection in the Bloodstream appeared first on GEN - Genetic Engineering and Biotechnology News.
Investors zeroed in on the mere 0.9% dip in body weight and 3.3% decline in waist circumference (both placebo-adjusted) reported in the 32-participant 240 mg dose cohort following a six-month follow-up review during the Phase I INLIGHT trial (NCT06842186), designed to assess WVE-007 in healthy individuals living with overweight or obesity conditions. The post Wave Plummets 50% on Obesity Data appeared first on GEN - Genetic Engineering and Biotechnology News.